{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:52:00Z","timestamp":1782172320719,"version":"3.54.5"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"NIH","award":["HD059454"],"award-info":[{"award-number":["HD059454"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The HIV protease inhibitor lopinavir inhibits\n            <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n            aspartic proteases (plasmepsins) and parasite development, and children receiving lopinavir-ritonavir experienced fewer episodes of malaria than those receiving other antiretroviral regimens. Resistance to lopinavir was selected\n            <jats:italic>in vitro<\/jats:italic>\n            over \u223c9 months, with \u223c4-fold decreased sensitivity. Whole-genome sequencing of resistant parasites showed a mutation and increased copy number in\n            <jats:italic>pfmdr1<\/jats:italic>\n            and a mutation in a protein of unknown function, but no polymorphisms in plasmepsin genes.\n          <\/jats:p>","DOI":"10.1128\/aac.01949-16","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T03:54:40Z","timestamp":1478577280000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in\n            <i>pfmdr1<\/i>"],"prefix":"10.1128","volume":"61","author":[{"given":"Ebere","family":"Sonoiki","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Nsanzabana","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Legac","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirthana M. 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