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Here we tested the\n            <jats:italic>in vitro<\/jats:italic>\n            and\n            <jats:italic>in vivo<\/jats:italic>\n            impacts of hyperbaric oxygen (HBO) (100% oxygen, &gt;1 atmosphere absolute [ATA]) on\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            proliferation and murine IPA outcomes. Our findings indicate that HBO reduces established fungal biofilm proliferation\n            <jats:italic>in vitro<\/jats:italic>\n            by over 50%. The effect of HBO under the treatment conditions was transient and fungistatic, with\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            metabolic activity rebounding within 6 h of HBO treatment being removed.\n            <jats:italic>In vivo<\/jats:italic>\n            , daily HBO provides a dose-dependent but modest improvement in murine IPA disease outcomes as measured by survival analysis. Intriguingly, no synergy was observed between subtherapeutic voriconazole or amphotericin B and HBO\n            <jats:italic>in vitro<\/jats:italic>\n            or\n            <jats:italic>in vivo<\/jats:italic>\n            with daily HBO dosing, though the loss of fungal superoxide dismutase genes enhanced HBO antifungal activity. Further studies are needed to optimize the HBO treatment regimen and better understand the effects of HBO on both the host and the pathogen during a pulmonary invasive fungal infection.\n          <\/jats:p>","DOI":"10.1128\/aac.01953-17","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T18:51:39Z","timestamp":1513018299000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Hyperbaric Oxygen Reduces Aspergillus fumigatus Proliferation\n            <i>In Vitro<\/i>\n            and Influences\n            <i>In Vivo<\/i>\n            Disease Outcomes"],"prefix":"10.1128","volume":"62","author":[{"given":"Sourabh","family":"Dhingra","sequence":"first","affiliation":[{"name":"Geisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Hanover, New Hampshire, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay C.","family":"Buckey","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth, Department of Medicine, Lebanon, New Hampshire, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Hanover, New Hampshire, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx028"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S81416"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.09.015"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ571"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020191"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01515-16"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01517-16"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw036"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000200"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00031-12"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002145"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077136"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00035-16"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004487"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-26-312-638"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1367"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006096"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-231209"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00346"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3064"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464180-00001"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm476"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06754.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910283"},{"key":"e_1_3_2_27_2","first-page":"R160","article-title":"Hypoxemia in the absence of blood loss or significant hypotension causes inflammatory cytokine release","volume":"269","author":"Ertel W","year":"1995","unstructured":"Ertel W, Morrison MH, Ayala A, Chaudry IH. 1995. 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