{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:28:11Z","timestamp":1766428091676,"version":"3.41.2"},"reference-count":10,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,2,21]]},"abstract":"<jats:p>\n            We report a case of a 62-year-old man treated for\n            <jats:named-content content-type=\"genus-species\">Streptococcus pneumoniae<\/jats:named-content>\n            meningitis by ceftriaxone and dexamethasone. After neurological improvement, neurological degradation by vasculitis occurred, despite effective concentrations of ceftriaxone in the serum and cerebrospinal fluid (CSF).\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            with increased MICs to third-generation-cephalosporins (3GC) was isolated from the ventricular fluid 10 days after the isolation of the first strain. Isolate analysis showed that a mutation in the penicillin-binding protein 2X (PBP2X) has occurred under treatment.\n          <\/jats:p>","DOI":"10.1128\/aac.01958-19","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T11:09:10Z","timestamp":1573556950000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Emergence of Ceftriaxone Resistance during a Case of Pneumococcal Meningitis with Fatal Evolution"],"prefix":"10.1128","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3135-5093","authenticated-orcid":false,"given":"A.","family":"Mizrahi","sequence":"first","affiliation":[{"name":"Laboratoire de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France"},{"name":"EA 4043 Unit\u00e9 Bact\u00e9ries Pathog\u00e8nes et Sant\u00e9, Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-0720","authenticated-orcid":false,"given":"J. C.","family":"Marvaud","sequence":"additional","affiliation":[{"name":"EA 4043 Unit\u00e9 Bact\u00e9ries Pathog\u00e8nes et Sant\u00e9, Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Pilmis","sequence":"additional","affiliation":[{"name":"EA 4043 Unit\u00e9 Bact\u00e9ries Pathog\u00e8nes et Sant\u00e9, Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, Paris, France"},{"name":"Equipe Mobile de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Nguyen Van","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Couzigou","sequence":"additional","affiliation":[{"name":"Equipe Mobile de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bruel","sequence":"additional","affiliation":[{"name":"R\u00e9animation Polyvalente, Groupe Hospitalier Paris Saint-Joseph, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Engrand","sequence":"additional","affiliation":[{"name":"R\u00e9animation NeuroChirurgicale, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Le Monnier","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France"},{"name":"EA 4043 Unit\u00e9 Bact\u00e9ries Pathog\u00e8nes et Sant\u00e9, Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France"},{"name":"EA 4043 Unit\u00e9 Bact\u00e9ries Pathog\u00e8nes et Sant\u00e9, Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70288-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-323"},{"key":"e_1_3_3_4_2","unstructured":"SPILF. 2018. Prise en charge des m\u00e9ningites bact\u00e9riennes aigu\u00ebs communautaires (\u00e0 l\u2019exclusion du nouveau-n\u00e9): Actualisation 2017 de la Conf\u00e9rence de Consensus 2008. Societe de Pathologie Infectieuse de Langue Fran\u00e7aise Paris France. https:\/\/www.infectiologie.com\/UserFiles\/File\/formation\/desc\/2017\/seminaire-avril-2017\/cours-mercredi-12.04\/recommandations-meningites-bacteriennes-xduval.pdf."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.17.3.364"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb01422.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.2.188"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.4.628"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.01.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003220"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw861"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01958-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01958-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:49:16Z","timestamp":1645480156000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01958-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,21]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2,21]]}},"alternative-id":["10.1128\/AAC.01958-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.01958-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[2020,2,21]]},"assertion":[{"value":"2019-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01958-19"}}