{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:30:23Z","timestamp":1781019023650,"version":"3.54.1"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:p>\n            Omadacycline is an aminomethylcycline antibiotic with\n            <jats:italic>in vitro<\/jats:italic>\n            activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against\n            <jats:named-content content-type=\"genus-species\">Legionella pneumophila<\/jats:named-content>\n            strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory infections. Omadacycline exhibited extracellular activity similar to comparator antibiotics; intracellular penetrance was found by day 3 of omadacycline exposure.\n          <\/jats:p>","DOI":"10.1128\/aac.01972-19","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T12:28:48Z","timestamp":1582201728000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["<i>In Vitro<\/i>\n            and Intracellular Activities of Omadacycline against Legionella pneumophila"],"prefix":"10.1128","volume":"64","author":[{"given":"Jacques","family":"Dubois","sequence":"first","affiliation":[{"name":"M360 Inc., Sherbrooke, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eft\u00e9e","family":"Dubois","sequence":"additional","affiliation":[{"name":"M360 Inc., Sherbrooke, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Martel","sequence":"additional","affiliation":[{"name":"M360 Inc., Sherbrooke, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1993"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2016.10.009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-350OC"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg191"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9862"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31827f6104"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00702002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2016.10.002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/341087"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40138-014-0056-4"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.15.3.506-526.2002"},{"key":"e_1_3_2_13_2","volume-title":"Antibiotic resistance threats in the United States","author":"Centers for Disease Control and Prevention","year":"2013","unstructured":"Centers for Disease Control and Prevention. 2013. Antibiotic resistance threats in the United States. Department of Health and Human Services, Washington, DC. https:\/\/www.cdc.gov\/drugresistance\/threat-report-2013\/pdf\/ar-threats-2013-508.pdf. Accessed 19 August 2019."},{"key":"e_1_3_2_14_2","volume-title":"Antimicrobial resistance: global report on surveillance","author":"World Health Organization","year":"2014","unstructured":"World Health Organization. 2014. Antimicrobial resistance: global report on surveillance. World Health Organization, Geneva, Switzerland. https:\/\/www.who.int\/drugresistance\/documents\/surveillancereport\/en\/. Accessed 19 August 2019."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01536-15"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01066-13"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01242-13"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00018-17"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2016-0100"},{"key":"e_1_3_2_20_2","volume-title":"Omadacycline U.S. prescribing information","author":"Paratek Pharmaceuticals, Inc","year":"2018","unstructured":"Paratek Pharmaceuticals, Inc. 2018. Omadacycline U.S. prescribing information. Paratek Pharmaceuticals, Inc., Boston, MA. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/209816_209817lbl.pdf. Accessed 16 September 2019."},{"key":"e_1_3_2_21_2","volume-title":"M100 Performance standards for antimicrobial susceptibility testing","author":"Clinical and Laboratory Standards Institute","year":"2019","unstructured":"Clinical and Laboratory Standards Institute. 2019. M100 Performance standards for antimicrobial susceptibility testing, 29th ed. Clinical and Laboratory Standards Institute, Wayne, PA. https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m100\/. Accessed 26 September 2019.","edition":"29"},{"key":"e_1_3_2_22_2","volume-title":"M07 Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically","author":"Clinical and Laboratory Standards Institute","year":"2018","unstructured":"Clinical and Laboratory Standards Institute. 2018. M07 Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 11th ed. Clinical and Laboratory Standards Institute, Wayne, PA. https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m07\/. Accessed 26 September 2019.","edition":"11"},{"key":"e_1_3_2_23_2","first-page":"159","volume-title":"Proceedings of the 2nd International Symposium of the American Society for Microbiology","author":"Horwitz MA","year":"1984","unstructured":"Horwitz MA. 1984. Legionella, 159\u2013166. In Proceedings of the 2nd International Symposium of the American Society for Microbiology. ASM Press, Washington, DC."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.5.1392-1398.1998"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01135-17"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800201"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01972-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01972-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:46:04Z","timestamp":1645479964000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01972-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,4,21]]}},"alternative-id":["10.1128\/AAC.01972-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.01972-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,21]]},"assertion":[{"value":"2019-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01972-19"}}