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Lapatinib not only significantly suppressed RSV replication\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      but also markedly reduced viral proliferation and mitigated inflammatory lung injury in a BALB\/c female mouse model. Mechanistic studies revealed that lapatinib inhibited RSV replication through the downregulation of interleukin-17 (IL-17). This effect was antagonized upon IL-17 overexpression, confirming the pivotal role of this cytokine. We further proposed that lapatinib exerted its antiviral effect by targeting ErbB1 and ErbB2 receptors, thereby disrupting IL-17\u2013mediated viral propagation. These findings provide both novel mechanistic insights and a compelling therapeutic direction for the treatment of RSV infection\u3002.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01972-25","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:14:48Z","timestamp":1782389688000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Anti-RSV drug screening and inhibition of RSV infection by lapatinib through the IL-17 pathway"],"prefix":"10.1128","volume":"70","author":[{"given":"Zheng","family":"Sun","sequence":"first","affiliation":[{"name":"School of Life Sciences, Anhui Medical University","place":["Hefei, 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