{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:34:25Z","timestamp":1789475665080,"version":"build-2803163510"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,1,20]]},"abstract":"<jats:p>\n                    Bisbenzylisoquinoline (BBIQ) alkaloids are a diverse group of natural products that demonstrate a range of biological activities. In this study, the\n                    <jats:italic>in vitro<\/jats:italic>\n                    antiplasmodial activity of three BBIQ alkaloids (cycleanine [compound 1], isochondodendrine [compound 2], and 2\u2032-norcocsuline [compound 3]) isolated from the\n                    <jats:named-content content-type=\"genus-species\">Triclisia subcordata<\/jats:named-content>\n                    Oliv. medicinal plant traditionally used for the treatment of malaria in Nigeria are studied alongside two semisynthetic analogues (compounds 4 and 5) of cycleanine.\n                  <\/jats:p>","DOI":"10.1128\/aac.01995-20","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T09:11:44Z","timestamp":1606813904000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["<i>In Vivo<\/i>\n                    Efficacy and Metabolism of the Antimalarial Cycleanine and Improved\n                    <i>In Vitro<\/i>\n                    Antiplasmodial Activity of Semisynthetic Analogues"],"prefix":"10.1128","volume":"65","author":[{"given":"Fidelia Ijeoma","family":"Uche","sequence":"first","affiliation":[{"name":"School of Pharmacy and Bioengineering, Keele University, Stoke-on-Trent, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhen","family":"Guo","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude","family":"Okokon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Ullah","sequence":"additional","affiliation":[{"name":"School of Medicine, Keele University, Stoke-on-Trent, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Horrocks","sequence":"additional","affiliation":[{"name":"School of Medicine, Keele University, Stoke-on-Trent, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Boateng","sequence":"additional","affiliation":[{"name":"School of Science, University of Greenwich, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggang","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3706-6068","authenticated-orcid":false,"given":"Wen-Wu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Bioengineering, Keele University, Stoke-on-Trent, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"World malaria report 2019","author":"WHO","year":"2019","unstructured":"WHO. 2019. 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