{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:19:39Z","timestamp":1776896379182,"version":"3.51.2"},"reference-count":64,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"VINNOVA VINNMER Marie-Curie","award":["2015-01505"],"award-info":[{"award-number":["2015-01505"]}]},{"DOI":"10.13039\/501100003745","name":"Wilhelm and Martina Lundgrens Foundation","doi-asserted-by":"crossref","award":["2016-1323"],"award-info":[{"award-number":["2016-1323"]}],"id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003745","name":"Wilhelm and Martina Lundgrens Foundation","doi-asserted-by":"crossref","award":["2017-1966"],"award-info":[{"award-number":["2017-1966"]}],"id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003745","name":"Wilhelm and Martina Lundgrens Foundation","doi-asserted-by":"crossref","award":["2018-2465"],"award-info":[{"award-number":["2018-2465"]}],"id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Lilla Barnets Fund","award":["20170806"],"award-info":[{"award-number":["20170806"]}]},{"name":"Anna-Brita and Bo Castegrens Memorial Foundation","award":["LA2017-0269"],"award-info":[{"award-number":["LA2017-0269"]}]},{"name":"ALF-agreement","award":["ALFGBG-722491"],"award-info":[{"award-number":["ALFGBG-722491"]}]},{"name":"ALF-agreement","award":["ALFGBG-813291"],"award-info":[{"award-number":["ALFGBG-813291"]}]},{"DOI":"10.13039\/501100001674","name":"Leducq Foundation","doi-asserted-by":"crossref","award":["DSRR_P34404"],"award-info":[{"award-number":["DSRR_P34404"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005701","name":"\u00c5hlen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005701","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Telethon Perth Children's Hospital Research Funds"},{"DOI":"10.13039\/501100003745","name":"Wilhelm and Martina Lundgrens Foundation","doi-asserted-by":"crossref","award":["2017-1911"],"award-info":[{"award-number":["2017-1911"]}],"id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003745","name":"Wilhelm and Martina Lundgrens Foundation","doi-asserted-by":"crossref","award":["2018-2368"],"award-info":[{"award-number":["2018-2368"]}],"id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cerebral Palsy Alliance Australia","award":["PG4416"],"award-info":[{"award-number":["PG4416"]}]},{"DOI":"10.13039\/501100001862","name":"Swedish Research Council Formas","doi-asserted-by":"publisher","award":["VR-2017-01409"],"award-info":[{"award-number":["VR-2017-01409"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Swedish Research Council Formas","doi-asserted-by":"publisher","award":["VR-2018-02682"],"award-info":[{"award-number":["VR-2018-02682"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007464","name":"Torsten S\u00f6derbergs Stiftelse","doi-asserted-by":"publisher","award":["M98\/15"],"award-info":[{"award-number":["M98\/15"]}],"id":[{"id":"10.13039\/100007464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008590","name":"STROKE-Riksf\u00f6rbundet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2017-0063"],"award-info":[{"award-number":["FO2017-0063"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["F018-0090"],"award-info":[{"award-number":["F018-0090"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,2,21]]},"abstract":"<jats:p>Infection is correlated with increased risk of neurodevelopmental sequelae in preterm infants. In modeling neonatal brain injury, Toll-like receptor agonists have often been used to mimic infections and induce inflammation. Using the most common cause of bacteremia in preterm infants,<jats:named-content content-type=\"genus-species\">Staphylococcus epidermidis<\/jats:named-content>, we present a more clinically relevant neonatal mouse model that addresses the combined effects of bacterial infection together with subsequent hypoxic-ischemic brain insult.<\/jats:p>","DOI":"10.1128\/aac.02003-19","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T13:42:47Z","timestamp":1575985367000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Vancomycin Is Protective in a Neonatal Mouse Model of<i>Staphylococcus epidermidis<\/i>-Potentiated Hypoxic-Ischemic Brain Injury"],"prefix":"10.1128","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-1469","authenticated-orcid":false,"given":"Jacqueline C. Y.","family":"Lai","sequence":"first","affiliation":[{"name":"Center for Perinatal Medicine and Health, Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Harvard Medical School, Harvard University, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernilla","family":"Svedin","sequence":"additional","affiliation":[{"name":"Center for Perinatal Medicine and Health, Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-7679","authenticated-orcid":false,"given":"C. Joakim","family":"Ek","sequence":"additional","affiliation":[{"name":"Center for Perinatal Medicine and Health, Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Mottahedin","sequence":"additional","affiliation":[{"name":"Center for Perinatal Medicine and Health, Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Perinatal Medicine and Health, Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Henan Key Laboratory of Child Brain Injury, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-1945","authenticated-orcid":false,"given":"Ofer","family":"Levy","sequence":"additional","affiliation":[{"name":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Harvard Medical School, Harvard University, Boston, Massachusetts, USA"},{"name":"Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5193-3404","authenticated-orcid":false,"given":"Andrew","family":"Currie","sequence":"additional","affiliation":[{"name":"Centre for Neonatal Research and Education, University of Western Australia, Perth, Western Australia, Australia"},{"name":"Medical, Molecular and Forensic Sciences, Murdoch University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Strunk","sequence":"additional","affiliation":[{"name":"Centre for Neonatal Research and Education, University of Western Australia, Perth, Western Australia, Australia"},{"name":"Neonatal Directorate, King Edward Memorial Hospital for Women, Subiaco, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8953-919X","authenticated-orcid":false,"given":"Carina","family":"Mallard","sequence":"additional","affiliation":[{"name":"Center for Perinatal Medicine and Health, Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Henan Key Laboratory of Child Brain Injury, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.01.004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70710-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13629"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306213"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/586076"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.128"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2015.00014"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00199"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004205.pub3"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1598596"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004205.pub3"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.20.12.1662"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.05.011"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.798290"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200001000-00014"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0673-13.2013"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17691292"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900762"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.007776"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.04.001"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367792780740549"},{"key":"e_1_3_3_23_2","first-page":"562","article-title":"The route of absorption of intraperitoneally administered compounds","volume":"178","author":"Lukas G","year":"1971","unstructured":"Lukas G, Brindle SD, Greengard P. 1971. The route of absorption of intraperitoneally administered compounds. J Pharmacol Exp Ther 178:562\u2013564.","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000163513.03619.8D"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv231"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2005.07.003"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.55782\/ane-2010-1796","article-title":"Sepsis induces apoptotic cell death in different regions of the brain in a rat model of sepsis","volume":"70","author":"Kafa IM","year":"2010","unstructured":"Kafa IM, Uysal M, Bakirci S, Kurt A. 2010. Sepsis induces apoptotic cell death in different regions of the brain in a rat model of sepsis. Acta Neurobiol Exp 70:246\u2013260.","journal-title":"Acta Neurobiol Exp"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000047087"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.11.019"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2016.00114"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1286-4579(02)01563-0"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmu079"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.06.001"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M909168199"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00653.x"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3520-14.2014"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03337329"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.10.010"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00597"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(93)90006-x"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161211798220918"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00755"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2014.921164"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.04.042"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010111"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.521-540.2005"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A1215-568R"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.02.004"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.25.17406"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.123"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23670"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1330-6"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0162-3109(96)00156-7"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2006.01112.x"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01462-18"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1471-4906(02)02259-7"},{"key":"e_1_3_3_57_2","first-page":"588","article-title":"Resident bacterial flora in the skin of C57BL\/6 mice housed under SPF conditions","volume":"49","author":"Tavakkol Z","year":"2010","unstructured":"Tavakkol Z, Samuelson D, deLancey Pulcini E, Underwood RA, Usui ML, Costerton JW, James GA, Olerud JE, Fleckman P. 2010. Resident bacterial flora in the skin of C57BL\/6 mice housed under SPF conditions. J Am Assoc Lab Anim Sci 49:588\u2013591.","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.1.175-183.1996"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00032-3"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-014-0153-z"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.34.6.1100"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181994a53"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00892-0"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1159\/000232561"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.255"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02003-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02003-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T10:55:26Z","timestamp":1722164126000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02003-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,21]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2,21]]}},"alternative-id":["10.1128\/AAC.02003-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.02003-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,21]]},"assertion":[{"value":"2019-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02003-19"}}