{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:20:48Z","timestamp":1791519648204,"version":"4.3.4"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Antistaphylococcal agents commonly lack activity against Gram-negative bacteria like\n Escherichia coli<\/jats:named-content>\n owing to the permeability barrier presented by the outer membrane and\/or the action of efflux transporters. When these intrinsic resistance mechanisms are artificially compromised, such agents almost invariably demonstrate antibacterial activity against Gram negatives. Here we show that this is not the case for the antibiotic daptomycin, whose target appears to be absent from\n E. coli<\/jats:named-content>\n and other Gram-negative pathogens.\n <\/jats:p>","DOI":"10.1128\/aac.02005-12","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:17:28Z","timestamp":1351729048000},"page":"637-639","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":137,"title":["The Target of Daptomycin Is Absent from Escherichia coli and Other Gram-Negative Pathogens"],"prefix":"10.1128","volume":"57","author":[{"given":"Christopher P.","family":"Randall","sequence":"first","affiliation":[{"name":"Antimicrobial Research Centre and School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine R.","family":"Mariner","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Centre and School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Chopra","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Centre and School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Centre and School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70018-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.56.3.395-411.1992"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399410001766"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00922-10"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb300269g"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.849-852.2005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(03)00199-7"},{"key":"e_1_3_2_9_2","volume-title":"Approved standard M07-A9.","author":"Clinical and Laboratory Standards Institute","year":"2012","unstructured":"Clinical and Laboratory Standards Institute. 2012. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 9th ed, vol 32, no. 2. Approved standard M07-A9. 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