{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:12:13Z","timestamp":1785363133695,"version":"3.55.0"},"reference-count":60,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000950","name":"Cancer Council South Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015015","name":"Government of South Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,2,17]]},"abstract":"<jats:p>Fluconazole has been associated with higher mortality compared with the echinocandins in patients treated for invasive candida infections. Underexposure from current fluconazole dosing regimens may contribute to these worse outcomes, so alternative dosing strategies require study.<\/jats:p>","DOI":"10.1128\/aac.02019-20","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T13:09:48Z","timestamp":1613480988000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Model-Optimized Fluconazole Dose Selection for Critically Ill Patients Improves Early Pharmacodynamic Target Attainment without the Need for Therapeutic Drug Monitoring"],"prefix":"10.1128","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9457-8262","authenticated-orcid":true,"given":"Indy","family":"Sandaradura","sequence":"first","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, NSW, Australia"},{"name":"Department of Microbiology, St Vincent\u2019s Hospital, Sydney, NSW, Australia"},{"name":"St Vincent\u2019s Clinical School, University of New South Wales, Sydney, NSW, Australia"},{"name":"School of Medicine, University of Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Wojciechowski","sequence":"additional","affiliation":[{"name":"Global Product Development, Pfizer, Inc., Groton, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J. E.","family":"Marriott","sequence":"additional","affiliation":[{"name":"Department of Microbiology, St Vincent\u2019s Hospital, Sydney, NSW, Australia"},{"name":"St Vincent\u2019s Clinical School, University of New South Wales, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard O.","family":"Day","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Clinical School, University of New South Wales, Sydney, NSW, Australia"},{"name":"Clinical Pharmacology &amp; Toxicology, St Vincent\u2019s Hospital, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-587X","authenticated-orcid":true,"given":"Sophie","family":"Stocker","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Clinical School, University of New South Wales, Sydney, NSW, Australia"},{"name":"Clinical Pharmacology &amp; Toxicology, St Vincent\u2019s Hospital, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie E.","family":"Reuter","sequence":"additional","affiliation":[{"name":"UniSA Clinical &amp; Health Sciences, University of South Australia, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(03)00801-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000221"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31818b3477"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-150"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis021"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12039"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12597"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12329"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000111"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0286-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1210.060389"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1077-9108(08)70211-1"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2497-3"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.04.024"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411173312001"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/374850"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066906"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2011.01297.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00424-11"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01088-16"},{"key":"e_1_3_3_23_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2018. Clinical breakpoints for fungi v 9.0. https:\/\/www.eucast.org\/astoffungi\/clinicalbreakpointsforantifungals\/. Accessed 1 June 2020."},{"key":"e_1_3_3_24_2","volume-title":"Performance standards for antimicrobial susceptibility testing.","author":"Clinical and Laboratory Standards Institute","year":"2020","unstructured":"Clinical and Laboratory Standards Institute. 2020. Performance standards for antimicrobial susceptibility testing. CLSI document M100-S30. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00296-07"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.2.599"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70036-2"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.6.753"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2008.025"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt508"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00705-08"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40588-015-0019-x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu657"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13113"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4780-6"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pix109"},{"key":"e_1_3_3_37_2","volume-title":"Annu Sci Meet 2017 Aus Soc Antimicrob","author":"Sandaradura I","year":"2017","unstructured":"Sandaradura I, Wojciechowski J, Reuter SE. 2017. Annu Sci Meet 2017 Aus Soc Antimicrob, paper 6.3."},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01276-16"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0758-3"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488407779422311"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-288"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-020-00280-y"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(05)81975-4"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku169"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00177"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00251-13"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000284"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-017-0235-8"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1080\/1120009X.2019.1646974"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13465"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-017-0082-8"},{"key":"e_1_3_3_52_2","unstructured":"RStudio Inc. 2013. Shiny. https:\/\/shiny.rstudio.com\/. Accessed 1 February 2017."},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.21"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-019-00886-4"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v040.i01"},{"key":"e_1_3_3_57_2","first-page":"1x1","article-title":"Simulation from ODE-based population PK\/PD and systems pharmacology models in R with mrgsolve","volume":"2","author":"Baron KT","year":"2015","unstructured":"Baron KT, Gastonguay MR, Bioavailability A, Ss I, Addl M. 2015. Simulation from ODE-based population PK\/PD and systems pharmacology models in R with mrgsolve. Omega 2:1x1.","journal-title":"Omega"},{"key":"e_1_3_3_58_2","volume-title":"Australian injectable drugs handbook.","author":"Burridge N","year":"2011","unstructured":"Burridge N, Deidun D (ed). 2011. Australian injectable drugs handbook. Society of Hospital Pharmacists of Australia, Collingwood, Australia."},{"key":"e_1_3_3_59_2","volume-title":"Diflucan product information.","author":"Pfizer","year":"2014","unstructured":"Pfizer. 2014. Diflucan product information. Pfizer."},{"key":"e_1_3_3_60_2","first-page":"S65","article-title":"Simple, automatic noncompartmental analysis: the PKNCA R package","volume":"42","author":"Buckeridge C","year":"2015","unstructured":"Buckeridge C, Duvvuri S. 2015. Simple, automatic noncompartmental analysis: the PKNCA R package. J Pharmacokinet 42:S65.","journal-title":"J Pharmacokinet"},{"key":"e_1_3_3_61_2","unstructured":"Sandaradura I Norris R Marriott D Day R Reuter S. 2016. Modelling and simulation of fluconazole in critically ill adult patients poster 217. World Conference on Pharmacometrics 22 August 2016."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02019-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02019-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:51:35Z","timestamp":1645480295000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02019-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2,17]]}},"alternative-id":["10.1128\/AAC.02019-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.02019-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"2020-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02019-20"}}