{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:15:35Z","timestamp":1787501735920,"version":"build-2736575974"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Since epidemiological cutoff values (ECVs) using CLSI MICs from multiple laboratories are not available for\n Candida<\/jats:named-content>\n spp. and the echinocandins, we established ECVs for anidulafungin and micafungin on the basis of wild-type (WT) MIC distributions (for organisms in a species-drug combination with no detectable acquired resistance mechanisms) for 8,210\n Candida albicans<\/jats:named-content>\n , 3,102\n C. glabrata<\/jats:named-content>\n , 3,976\n C. parapsilosis<\/jats:named-content>\n , 2,042\n C. tropicalis<\/jats:named-content>\n , 617\n C. krusei<\/jats:named-content>\n , 258\n C. lusitaniae<\/jats:named-content>\n , 234\n C. guilliermondii<\/jats:named-content>\n , and 131\n C. dubliniensis<\/jats:named-content>\n isolates. CLSI broth microdilution MIC data gathered from 15 different laboratories in Canada, Europe, Mexico, Peru, and the United States were aggregated to statistically define ECVs. ECVs encompassing 97.5% of the statistically modeled population for anidulafungin and micafungin were, respectively, 0.12 and 0.03 \u03bcg\/ml for\n C. albicans<\/jats:named-content>\n , 0.12 and 0.03 \u03bcg\/ml for\n C. glabrata<\/jats:named-content>\n , 8 and 4 \u03bcg\/ml for\n C. parapsilosis<\/jats:named-content>\n , 0.12 and 0.06 \u03bcg\/ml for\n C. tropicalis<\/jats:named-content>\n , 0.25 and 0.25 \u03bcg\/ml for\n C. krusei<\/jats:named-content>\n , 1 and 0.5 \u03bcg\/ml for\n C. lusitaniae<\/jats:named-content>\n , 8 and 2 \u03bcg\/ml for\n C. guilliermondii<\/jats:named-content>\n , and 0.12 and 0.12 \u03bcg\/ml for\n C. dubliniensis<\/jats:named-content>\n . Previously reported single and multicenter ECVs defined in the present study were quite similar or within 1 2-fold dilution of each other. For a collection of 230 WT isolates (no\n fks<\/jats:italic>\n mutations) and 51 isolates with\n fks<\/jats:italic>\n mutations, the species-specific ECVs for anidulafungin and micafungin correctly classified 47 (92.2%) and 51 (100%) of the\n fks<\/jats:italic>\n mutants, respectively, as non-WT strains. These ECVs may aid in detecting non-WT isolates with reduced susceptibility to anidulafungin and micafungin due to\n fks<\/jats:italic>\n mutations.\n <\/jats:p>","DOI":"10.1128\/aac.02020-13","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T22:28:07Z","timestamp":1385418487000},"page":"916-922","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":49,"title":["Multicenter Study of Anidulafungin and Micafungin MIC Distributions and Epidemiological Cutoff Values for Eight Candida Species and the CLSI M27-A3 Broth Microdilution Method"],"prefix":"10.1128","volume":"58","author":[{"given":"M. A.","family":"Pfaller","sequence":"first","affiliation":[{"name":"JMI Laboratories, North Liberty, Iowa, USA"},{"name":"University of Iowa College of Medicine, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Espinel-Ingroff","sequence":"additional","affiliation":[{"name":"VCU Medical Center, Richmond, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Alexander Von Humboldt-Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Canton","sequence":"additional","affiliation":[{"name":"Unidad de Microbiologia Experimental, Centro de Investigacion, Hospital Universitario La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Diekema","sequence":"additional","affiliation":[{"name":"University of Iowa College of Medicine, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fothergill","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fuller","sequence":"additional","affiliation":[{"name":"The University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Universidad Auton\u00f3ma de Nuevo Le\u00f3n, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Guarro","sequence":"additional","affiliation":[{"name":"Facultat de Medicina, IISPV, URV, Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lass-Fl\u00f6rl","sequence":"additional","affiliation":[{"name":"The Innsbruck Medical University, Division of Hygiene and Medical Microbiology, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Martin-Mazuelos","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Valme, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Meis","sequence":"additional","affiliation":[{"name":"Canisius Wilhelmina Hospital, Nijmegen, Netherlands"},{"name":"Radboud University Hospital, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ostrosky-Zeichner","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Pelaez","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u0148\u00f3n, Facultad de Medicina-Universidad Complutense, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"St-Germain","sequence":"additional","affiliation":[{"name":"Laboratoire de Sant\u00e9 Publique du Qu\u00e9bec, Institut National de Sant\u00e9 Publique du Qu\u00e9bec, Quebec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Turnidge","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12039"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/596757"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12041"},{"key":"e_1_3_2_5_2","volume-title":"M27-A3. Reference method for broth dilution antifungal susceptibility testing of yeasts","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. M27-A3. Reference method for broth dilution antifungal susceptibility testing of yeasts, 3rd ed. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"3"},{"key":"e_1_3_2_6_2","volume-title":"M27-S4. Reference method for broth dilution antifungal susceptibility testing of yeasts, 4th informational supplement","author":"Clinical and Laboratory Standards Institute","year":"2012","unstructured":"Clinical and Laboratory Standards Institute. 2012. M27-S4. Reference method for broth dilution antifungal susceptibility testing of yeasts, 4th informational supplement. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2011.01.004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00937-12"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01590-09"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg312"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-011-0053-y"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm423"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00047-06"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05047-11"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01519-13"},{"key":"e_1_3_2_16_2","volume-title":"Minutes and agenda: Annual Meeting of Subcommittee for Antifungal Susceptibility Testing, Tampa, FL, 22 January 2013","author":"Clinical and Laboratory Standards Institute","year":"2013","unstructured":"Clinical and Laboratory Standards Institute. 2013. Minutes and agenda: Annual Meeting of Subcommittee for Antifungal Susceptibility Testing, Tampa, FL, 22 January 2013. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00636-13"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01730-12"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01377.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01457-06"},{"key":"e_1_3_2_21_2","first-page":"121","article-title":"In vitro antifungal activities of anidulafungin and micafungin, licensed agents and the investigational triazole posaconazole as determined by NCCLS methods for 12,052 fungal isolates: review of literature","volume":"20","author":"Espinel-Ingroff A","year":"2003","unstructured":"Espinel-IngroffA. 2003. In vitro antifungal activities of anidulafungin and micafungin, licensed agents and the investigational triazole posaconazole as determined by NCCLS methods for 12,052 fungal isolates: review of literature. Rev. Iberoam. Micol. 20:121\u2013136.","journal-title":"Rev. Iberoam. Micol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.5.1782-1787.2006"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00308-13"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.4.1604-1607.2005"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00493-08"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01256-09"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02445-09"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00836-10"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02020-13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02020-13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:35:43Z","timestamp":1645464943000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02020-13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1128\/AAC.02020-13"],"URL":"https:\/\/doi.org\/10.1128\/aac.02020-13","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"2013-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}