{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:12:02Z","timestamp":1769505122075,"version":"3.49.0"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100013076","name":"MOST | National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX10722301-001"],"award-info":[{"award-number":["2018ZX10722301-001"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Hospital Authority Ascent Plan","award":["DFL20191601"],"award-info":[{"award-number":["DFL20191601"]}]},{"name":"Beijing Hospital Authority Clinical Medicine Development of Special Funding","award":["ZYLX202122"],"award-info":[{"award-number":["ZYLX202122"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:p>Corrected QT duration (QTc) interval prolongation is the most frequent adverse event associated with bedaquiline (BDQ) use. It may affect the safety of antituberculosis therapy, which leads to the consequent demands of needing to monitor during therapy.<\/jats:p>","DOI":"10.1128\/aac.02033-21","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T13:00:30Z","timestamp":1662037230000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Development and Validation of a Nomogram for Prediction of QT Interval Prolongation in Patients Administered Bedaquiline-Containing Regimens in China: a Modeling Study"],"prefix":"10.1128","volume":"66","author":[{"given":"Fangchao","family":"Liu","sequence":"first","affiliation":[{"name":"Clinical Center on TB, Beijing Chest Hospital, Capital Medical University\/Beijing Tuberculosis &amp; Thoracic Tumor Research Institute, Beijing, People\u2019s Republic of China"},{"name":"Department of Science and Technology, Beijing Chest Hospital, Capital Medical University\/Beijing Tuberculosis &amp; Thoracic Tumor Research Institute, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingtao","family":"Gao","sequence":"additional","affiliation":[{"name":"Clinical Center on TB, Beijing Chest Hospital, Capital Medical University\/Beijing Tuberculosis &amp; Thoracic Tumor Research Institute, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqiu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University\/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Center on TB, Beijing Chest Hospital, Capital Medical University\/Beijing Tuberculosis &amp; Thoracic Tumor Research Institute, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shu","sequence":"additional","affiliation":[{"name":"Clinical Center on TB, Beijing Chest Hospital, Capital Medical University\/Beijing Tuberculosis &amp; Thoracic Tumor Research Institute, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University\/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxian","family":"Sun","sequence":"additional","affiliation":[{"name":"Clinical Center on TB, Beijing Chest Hospital, Capital Medical University\/Beijing Tuberculosis &amp; Thoracic Tumor Research Institute, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Center on TB, Beijing Chest Hospital, Capital Medical University\/Beijing Tuberculosis &amp; Thoracic Tumor Research Institute, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Center on TB, Beijing Chest Hospital, Capital Medical University\/Beijing Tuberculosis &amp; Thoracic Tumor Research Institute, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6803-9807","authenticated-orcid":true,"given":"Yu","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Beijing Chest Hospital, Capital Medical University\/Beijing Tuberculosis &amp; Thoracic Tumor Research Institute, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31882-3"},{"key":"e_1_3_3_3_2","volume-title":"Global tuberculosis report.","author":"World Health Organization","year":"2020","unstructured":"World Health Organization. 2020. Global tuberculosis report. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30110-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.112228"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv054"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500106"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00900-17"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313865"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.06.004"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01799-2016"},{"key":"e_1_3_3_12_2","volume-title":"WHO consolidated guidelines on drug-resistant tuberculosis treatment.","author":"World Health Organization","year":"2019","unstructured":"World Health Organization. 2019. WHO consolidated guidelines on drug-resistant tuberculosis treatment. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01462-2017"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2019.1648429"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.21.0403"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-021-00396-9"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71116-7"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2203.151430"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01207-2016"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01386-2018"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku171"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2012.657626"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12699"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200111000-00006"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx317"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2021.02.017"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4197-7"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000168"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2016-0179"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02125-19"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.14.0335"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.113.000651"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-77244-8"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970228)16:4%3C385::AID-SIM380%3E3.0.CO;2-3"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3462-1"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00341-9"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc13814"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.02033-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.02033-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T13:12:29Z","timestamp":1663679549000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.02033-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,20]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,20]]}},"alternative-id":["10.1128\/aac.02033-21"],"URL":"https:\/\/doi.org\/10.1128\/aac.02033-21","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,20]]},"assertion":[{"value":"2021-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02033-21"}}