{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:41:44Z","timestamp":1791312104744,"version":"4.3.1"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Fifty-seven carbapenem-resistant\n Klebsiella pneumoniae<\/jats:named-content>\n isolates belonging to ST11 (50 isolates), ST423 (5 isolates), and two other sequence types were studied. All were positive for\n bla<\/jats:italic>\n KPC-2<\/jats:sub>\n ,\n bla<\/jats:italic>\n TEM-1<\/jats:sub>\n , and\n bla<\/jats:italic>\n CTX-M-14<\/jats:sub>\n . SDS-PAGE analysis of six representative isolates demonstrated varied porin expression. Nevertheless, when\n bla<\/jats:italic>\n KPC-2<\/jats:sub>\n was deleted, carbapenem resistance was markedly reduced. Additionally, SHV-12, DHA-1, and\/or VIM-1 appeared to contribute to accessory carbapenemase activity. In contrast, OmpK35 and\/or OmpK36 deficiency seemed to serve only as a minor cooperative factor.\n <\/jats:p>","DOI":"10.1128\/aac.02045-12","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T22:28:07Z","timestamp":1385418487000},"page":"1214-1217","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":61,"title":["Contribution of \u03b2-Lactamases and Porin Proteins OmpK35 and OmpK36 to Carbapenem Resistance in Clinical Isolates of KPC-2-Producing Klebsiella pneumoniae"],"prefix":"10.1128","volume":"58","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Huashan 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