{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:09:57Z","timestamp":1759410597745,"version":"3.41.2"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["PI14\/01693"],"award-info":[{"award-number":["PI14\/01693"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["PI16\/01863"],"award-info":[{"award-number":["PI16\/01863"]}]},{"name":"Proyecto de Investigaci\u00f3n de Excelencia","award":["CTS2593"],"award-info":[{"award-number":["CTS2593"]}]},{"name":"Spanish AIDS Research Network of Excellence","award":["RD16\/0025\/0019"],"award-info":[{"award-number":["RD16\/0025\/0019"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria, Miguel Servet II","award":["CPII13\/00037"],"award-info":[{"award-number":["CPII13\/00037"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria, Miguel Servet II","award":["CPII014\/00025"],"award-info":[{"award-number":["CPII014\/00025"]}]},{"name":"Junta de Andaluc\u00eda, Nicol\u00e1s Monardes","award":["C-0010\/13"],"award-info":[{"award-number":["C-0010\/13"]}]},{"DOI":"10.13039\/501100004587","name":"MINECO | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI00\/00431"],"award-info":[{"award-number":["FI00\/00431"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","award":["205644"],"award-info":[{"award-number":["205644"]}],"id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The response to the HBV vaccine in HIV-infected patients is deficient. Our aim was to analyze whether a suppressive combined antiretroviral treatment (cART) containing maraviroc (MVC-cART) was associated with a better response to HBV vaccine. Fifty-seven patients on suppressor cART were administered the HBV vaccine. The final response, the early response, and the maintenance of the response were assessed. An anti-HBs titer of &gt;10 mIU\/ml was considered a positive response. A subgroup of subjects was simultaneously vaccinated against hepatitis A virus (HAV). Lineal regression analyses were performed to determine demographic, clinical, and immunological factors associated with the anti-HBs titer. Vaccine response was achieved in 90% of the subjects. After 1 year, 81% maintained protective titers. Only simultaneous HAV vaccination was independently associated with the magnitude of the response in anti-HBs titers, with a\n            <jats:italic>P<\/jats:italic>\n            value of 0.045 and a regression coefficient (B) [95% confident interval (CI)] of 236 [5 to 468]. In subjects \u226450 years old (\n            <jats:italic>n<\/jats:italic>\n            = 42), MVC-cART was independently associated with the magnitude of the response (\n            <jats:italic>P<\/jats:italic>\n            = 0.009; B [95% CI], 297 [79 to 516]) together with previous vaccination and simultaneous HAV vaccination. High rates of HBV vaccine response can be achieved by revaccination, simultaneous HAV vaccination, and administration of cARTs including MVC. MVC may be considered for future vaccination protocols in patients on suppressive cART.\n          <\/jats:p>","DOI":"10.1128\/aac.02050-17","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T15:50:31Z","timestamp":1509378631000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Association between a Suppressive Combined Antiretroviral Therapy Containing Maraviroc and the Hepatitis B Virus Vaccine Response"],"prefix":"10.1128","volume":"62","author":[{"given":"In\u00e9s","family":"Herrero-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Laboratory of Immunovirology, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda M.","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Genebat","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda del Mar","family":"Rodriguez-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda del Carmen","family":"Lozano","sequence":"additional","affiliation":[{"name":"Microbiology Service, Virgen del Roc\u00edo University Hospital, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Polaino","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Rosado-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Taranc\u00f3n-Diez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Mu\u00f1oz-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Molecular Immunobiology Laboratory, General Universitary Hospital Gregorio Mara\u00f1on, Health Research Institute Gregorio Mara\u00f1on, Spanish HIV HGM BioBank, Madrid, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezequiel","family":"Ruiz-Mateos","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Leal","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80001-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11913-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70243-8"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit937"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/433180"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.11.057"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.351"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.08.011"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01406-12"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu180"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/653707"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2012.00206"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042909-093756"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2174\/157016211797636008"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv520"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1201248"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-735076"},{"key":"e_1_3_3_19_2","first-page":"869","article-title":"Treatment with the C-C chemokine receptor type 5 (CCR5)-inhibitor maraviroc suppresses growth and induces apoptosis of acute lymphoblastic leukemia cells","volume":"7","author":"Zi J","year":"2017","unstructured":"Zi J, Yuan S, Qiao J, Zhao K, Xu L, Qi K, Xu K, Zeng L. 2017. Treatment with the C-C chemokine receptor type 5 (CCR5)-inhibitor maraviroc suppresses growth and induces apoptosis of acute lymphoblastic leukemia cells. Am J Cancer Res 7:869\u2013880.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005540"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ455"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.12.025"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080409"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.07.028"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.11.066"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.10.040"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/589722"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1310\/hct1105-332"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2014.1004026"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13468"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/524690"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.02.014"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.02.046"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70049-9"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit006"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv202"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2006.19.759"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02050-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02050-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:10:11Z","timestamp":1645477811000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02050-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1128\/AAC.02050-17"],"URL":"https:\/\/doi.org\/10.1128\/aac.02050-17","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02050-17"}}