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Secondary objectives included characterization of epithelial lining fluid (ELF)\/plasma penetration ratios and determination of the probability of target attainment (PTA) for a range of MICs. Thirty-two mechanically ventilated patients who were treated for pneumonia with 6 g of temocillin daily for\n            <jats:italic>in vitro<\/jats:italic>\n            sensitive pathogens were assigned to either the II (2 g every 8 h over 0.5 h) or the CI (6 g over 24 h after a loading dose of 2 g) group.\n          <\/jats:p>","DOI":"10.1128\/aac.02052-21","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T16:22:55Z","timestamp":1643646175000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Modelled Target Attainment after Temocillin Treatment in Severe Pneumonia: Systemic and Epithelial Lining Fluid Pharmacokinetics of Continuous versus Intermittent Infusions"],"prefix":"10.1128","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1360-4917","authenticated-orcid":true,"given":"N.","family":"Layios","sequence":"first","affiliation":[{"name":"University Hospital of Li\u00e8ge, Service des Soins Intensifs, Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Vis\u00e9e","sequence":"additional","affiliation":[{"name":"University Hospital of Li\u00e8ge, Service des Maladies Infectieuses, Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Mistretta","sequence":"additional","affiliation":[{"name":"University Hospital of Li\u00e8ge, Service de Toxicologie Clinique, Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Denooz","sequence":"additional","affiliation":[{"name":"University Hospital of Li\u00e8ge, Service de Toxicologie Clinique, Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Maes","sequence":"additional","affiliation":[{"name":"University Hospital of Li\u00e8ge, Service d\u2019Informations m\u00e9dico-\u00e9conomiques, Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Descy","sequence":"additional","affiliation":[{"name":"University Hospital of Li\u00e8ge, Service de Microbiologie Clinique, Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Frippiat","sequence":"additional","affiliation":[{"name":"University Hospital of Li\u00e8ge, Service des Maladies Infectieuses, Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-6678","authenticated-orcid":true,"given":"S.","family":"Marchand","sequence":"additional","affiliation":[{"name":"INSERM U1070, Poitiers Cedex, France"},{"name":"Universit\u00e9 de Poitiers, UFR de M\u00e9decine Pharmacie, Poitiers Cedex, France"},{"name":"CHU de Poitiers, d\u00e9partement de toxicologie et pharmacocin\u00e9tique, Poitiers Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Gr\u00e9goire","sequence":"additional","affiliation":[{"name":"INSERM U1070, Poitiers Cedex, France"},{"name":"Universit\u00e9 de Poitiers, UFR de M\u00e9decine Pharmacie, Poitiers Cedex, France"},{"name":"CHU de Poitiers, d\u00e9partement de toxicologie et pharmacocin\u00e9tique, Poitiers Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl043"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp208"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr317"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm467"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku465"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.02.002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30615-1"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-017-0439-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-017-0584-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(03)00065-5"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm179"},{"key":"e_1_3_3_13_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2021. 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