{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:03:11Z","timestamp":1792040591052,"version":"4.4.0"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Project 001"],"award-info":[{"award-number":["Project 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009037","name":"MEXT | JST | Science and Technology Research Partnership for Sustainable Development","doi-asserted-by":"publisher","award":["02-P9427\/2018"],"award-info":[{"award-number":["02-P9427\/2018"]}],"id":[{"id":"10.13039\/501100009037","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,2,21]]},"abstract":"<jats:p>\n            Azole antifungal resistance in\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            is a worldwide concern. As in most public hospitals in Brazil, antifungal susceptibility tests are not routinely performed for filamentous fungi at our institution. A 4-year retrospective azole antifungal resistance screening revealed two azole-resistant\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            clinical isolates carrying the CYP51A TR34 (34-bp tandem repeat)\/L98H (change of L to H at position 98)\/S297T\/F495I resistance mechanism mutations, obtained from two unrelated patients.\n          <\/jats:p>","DOI":"10.1128\/aac.02059-19","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T13:53:38Z","timestamp":1577195618000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Aspergillus fumigatus Clinical Isolates Carrying CYP51A with TR34\/L98H\/S297T\/F495I Substitutions Detected after Four-Year Retrospective Azole Resistance Screening in Brazil"],"prefix":"10.1128","volume":"64","author":[{"given":"La\u00eds","family":"Pontes","sequence":"first","affiliation":[{"name":"School of Medical Sciences, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Augusto Gualtieri","family":"Beraquet","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Arai","sequence":"additional","affiliation":[{"name":"Medical Mycology Research Center, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Leite","family":"Pigolli","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luzia","family":"Lyra","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Medical Mycology Research Center, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza","family":"Moretti","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-5054","authenticated-orcid":false,"given":"Ang\u00e9lica Zaninelli","family":"Schreiber","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2019.09.011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.1.44-69.2005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186422"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00865-19"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr443"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02478-15"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2106.140717"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2016.12.004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep45631"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00872-18"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myz032"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12759"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00608-17"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2017.10.005"},{"key":"e_1_3_2_16_2","unstructured":"Denardi LB Melchers WJG Zoll J Buil J Hagen F Meis JFG Alves SH Verweij PE. 2018. First report of azole-resistant Aspergillus fumigatus harboring TR34\/L98H and M220R in Brazil abstr S6.6c. 20th Congr Int Soc Human Anim Mycol (ISHAM 20th). https:\/\/www.aspergillus.org.uk\/conference_abstracts\/first-report-azole-resistant-aspergillus-fumigatus-harboring-tr34l98h-and-m220r."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01549-17"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13008"},{"key":"e_1_3_2_19_2","unstructured":"Reichert-Lima F. 2018. Avalia\u00e7\u00e3o de isolados cl\u00ednicos e ambientais de Aspergillus spp.: caracteriza\u00e7\u00e3o morfol\u00f3gica e molecular de esp\u00e9cies perfil de suscetibilidade e busca por muta\u00e7\u00f5es relacionadas \u00e0 resist\u00eancia aos antif\u00fangicos az\u00f3licos. PhD thesis. Universidade Estadual de Campinas Campinas Brazil. http:\/\/repositorio.unicamp.br\/jspui\/bitstream\/REPOSIP\/332836\/1\/Lima_FranquelineReichert_D.pdf."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05990-11"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf00437084"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3114\/sim.2007.59.05"},{"key":"e_1_3_2_23_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard, 2nd ed. CLSI M38-A2. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"2"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02059-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02059-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:45:16Z","timestamp":1645479916000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02059-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,21]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2,21]]}},"alternative-id":["10.1128\/AAC.02059-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.02059-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,21]]},"assertion":[{"value":"2019-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02059-19"}}