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While studying the modulatory effect of MRP-1 on anti-hepatitis C virus (HCV) direct-acting antiviral (DAA) efficiency, we observed an unexpected anti-HCV effect of compound MK-571 alone. This anti-HCV activity was characterized in Huh7.5 cells stably harboring a subgenomic genotype 1b replicon. A dose-dependent decrease of HCV RNA levels was observed upon MK-571 administration, with a 50% effective concentration (EC\n            <jats:sub>50<\/jats:sub>\n            \u2009\u00b1\u2009standard deviation) of 9\u2009\u00b1\u20090.\n          <\/jats:p>","DOI":"10.1128\/aac.02078-19","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T10:10:31Z","timestamp":1584007831000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["MK-571, a Cysteinyl Leukotriene Receptor 1 Antagonist, Inhibits Hepatitis C Virus Replication"],"prefix":"10.1128","volume":"64","author":[{"given":"Isaac","family":"Ruiz","sequence":"first","affiliation":[{"name":"Institut Mondor de Recherche Biom\u00e9dicale (IMRB), INSERM U955, Team \u201cViruses, Hepatology, Cancers\u201d, H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est, Cr\u00e9teil, France"},{"name":"Department of Hepatology, H\u00f4pital 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