{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:33:27Z","timestamp":1769632407135,"version":"3.49.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Invasive<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida<\/jats:named-content>infections associated with medical devices are very difficult to cure without device removal. We present a case of neonatal cerebrospinal fluid shunt-associated<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida<\/jats:named-content>meningitis, in which removal of the device was precluded, that was successfully treated with caspofungin. Pharmacokinetic assessment of caspofungin concentrations in cerebrospinal fluid showed that exposure was adequate in the presence of a high systemic exposure. In complex cases of neonatal<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida<\/jats:named-content>infections involving medical devices, the addition of caspofungin might be beneficial.<\/jats:p>","DOI":"10.1128\/aac.02085-12","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T04:56:06Z","timestamp":1361854566000},"page":"2391-2393","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Favorable Outcome of Neonatal Cerebrospinal Fluid Shunt-Associated Candida Meningitis with Caspofungin"],"prefix":"10.1128","volume":"57","author":[{"given":"Jop","family":"Jans","sequence":"first","affiliation":[{"name":"Departments of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger J. M.","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Pharmacy, Radboud University Medical Centre, Nijmegen, Netherlands"},{"name":"Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Christmann","sequence":"additional","affiliation":[{"name":"Neonatology, Radboud University Medical Centre, Nijmegen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands"},{"name":"Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adilia","family":"Warris","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, Netherlands"},{"name":"Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2292"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01701-10"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01569-10"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00856-07"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00697-10"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1097\/01.inf.0000145408.51526.0a","article-title":"Caspofungin therapy of neonates with invasive candidiasis","volume":"23","author":"Odio CM","year":"2004","unstructured":"OdioCM ArayaR PintoLE CastroCE VasquezS AlfaroB SaenzA HerreraML WalshTJ. 2004. 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