{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:13:18Z","timestamp":1790363598009,"version":"4.1.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Viable but noninfectious (stressed\/persistent) chlamydiae are more resistant to azithromycin (AZM) in culture than are organisms in the normal developmental cycle.\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Chlamydia muridarum<\/jats:named-content>\n            -infected mice were exposed to amoxicillin to induce the organisms to enter the persistent\/stressed state and subsequently treated with AZM. AZM treatment failure was observed in 22% of persistently infected mice, with an average of 321,667 inclusion-forming units (IFU) shed after AZM treatment. Productively infected mice had a 9% rate of AZM treatment failure and shed an average of 12,083 IFU. These data suggest that stressed chlamydiae are more resistant to frontline antichlamydial drugs\n            <jats:italic>in vivo<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.02097-13","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T02:23:13Z","timestamp":1387246993000},"page":"1782-1784","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["Induction of the Chlamydia muridarum Stress\/Persistence Response Increases Azithromycin Treatment Failure in a Murine Model of Infection"],"prefix":"10.1128","volume":"58","author":[{"given":"R.","family":"Phillips-Campbell","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kintner","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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Sexually transmitted diseases treatment guidelines\u20132002. MMWR Morb. Mortal. Wkly. Rep. 51:1\u201378.","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.9.1937"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0956462412472815"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2005.019158"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/428290"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis356"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/315778"},{"key":"e_1_3_2_18_2","first-page":"26","article-title":"Determining antimicrobial resistance to Chlamydia trachomatis and applying present findings in daily practice","volume":"7","author":"Sternak SL","year":"2010","unstructured":"SternakSLSkerkV. 2010. 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