{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:56:39Z","timestamp":1782388599944,"version":"3.54.5"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,6,21]]},"abstract":"<jats:p>\n            Activated platelets have known antimicrobial activity against\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            . Accelerated clearance of platelets induced by\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            can result in thrombocytopenia and increased mortality in patients.\n          <\/jats:p>","DOI":"10.1128\/aac.02117-21","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:01:11Z","timestamp":1649854871000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Impact of Clopidogrel on Clinical Outcomes in Patients with Staphylococcus aureus Bacteremia: a National Retrospective Cohort Study"],"prefix":"10.1128","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4180-027X","authenticated-orcid":true,"given":"Aisling R.","family":"Caffrey","sequence":"first","affiliation":[{"name":"Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"},{"name":"Center of Innovation in Long-Term Support Services, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"},{"name":"College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA"},{"name":"Warren Alpert Medical School of Brown University, Division of Infectious Diseases, Providence, Rhode Island, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2407-7032","authenticated-orcid":true,"given":"Haley J.","family":"Appaneal","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"},{"name":"Center of Innovation in Long-Term Support Services, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"},{"name":"College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9650-4275","authenticated-orcid":true,"given":"Kerry L.","family":"LaPlante","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"},{"name":"Center of Innovation in Long-Term Support Services, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"},{"name":"College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA"},{"name":"School of Public Health, Brown University, Providence, Rhode Island, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrishali V.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlinda R.","family":"Ulloa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, Irvine School of Medicine, Irvine, California, USA"},{"name":"Division of Infectious Disease, Children\u2019s Hospital of Orange County, Orange, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-0422","authenticated-orcid":true,"given":"Victor","family":"Nizet","sequence":"additional","affiliation":[{"name":"University of California, San Diego School of Medicine, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sakoulas","sequence":"additional","affiliation":[{"name":"University of California, San Diego School of Medicine, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012615-044351"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.24.3012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.632706"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab146"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd6737"},{"key":"e_1_3_3_7_2","first-page":"562","article-title":"Ticagrelor (Brilinta), an antiplatelet drug for acute coronary syndrome","volume":"37","author":"Fuller R","year":"2012","unstructured":"Fuller R, Chavez B. 2012. Ticagrelor (Brilinta), an antiplatelet drug for acute coronary syndrome. P T 37:562\u2013568.","journal-title":"P T"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3269"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0705"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05022-11"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170236"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2505.181733"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab452"},{"key":"e_1_3_3_14_2","unstructured":"Chiesi USA Inc. 2020. Cangrelor prescribing information. https:\/\/resources.chiesiusa.com\/Kengreal\/KENGREAL_US_PI.pdf."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00935-08"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.11.4652-4660.1997"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(03)00829-5"},{"key":"e_1_3_3_18_2","unstructured":"Clinical Classifications Software (CCS). 2017. Healthcare Cost and Utilization Project (HCUP). Agency for Healthcare Research and Quality Rockville MD."},{"key":"e_1_3_3_19_2","unstructured":"Clinical Classifications Software Refined (CCSR). 2021. Healthcare Cost and Utilization Project (HCUP). Agency for Healthcare Research and Quality Rockville MD. www.hcup-us.ahrq.gov\/toolssoftware\/ccsr\/ccs_refined.jsp."},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-017-0501-x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1214\/09-STS313"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-015-0017-y"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.02117-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.02117-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T14:53:01Z","timestamp":1655823181000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.02117-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,21]]}},"alternative-id":["10.1128\/aac.02117-21"],"URL":"https:\/\/doi.org\/10.1128\/aac.02117-21","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]},"assertion":[{"value":"2021-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02117-21"}}