{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:11:48Z","timestamp":1787796708541,"version":"build-2784847793"},"reference-count":59,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Deletants of the sphingolipid biosynthetic pathway genes\n            <jats:italic>FEN1<\/jats:italic>\n            and\n            <jats:italic>SUR4<\/jats:italic>\n            of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Saccharomyces cerevisiae<\/jats:named-content>\n            , as well as deletants of their orthologs in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida albicans<\/jats:named-content>\n            , were found to be 2- to 5-fold-more sensitive to amphotericin B (AmB) than parent strains. The inhibition of sphingolipid biosynthesis in parent strains by myriocin sensitized them to AmB, which can be reversed by providing phytosphingosine, an intermediate in the sphingolipid pathway. These results indicate that sphingolipids modulate AmB resistance, with implications for mechanisms underlying AmB action and resistance.\n          <\/jats:p>","DOI":"10.1128\/aac.02130-13","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T03:18:30Z","timestamp":1389064710000},"page":"2409-2414","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":59,"title":["Sphingolipid Biosynthetic Pathway Genes\n            <i>FEN1<\/i>\n            and\n            <i>SUR4<\/i>\n            Modulate Amphotericin B Resistance"],"prefix":"10.1128","volume":"58","author":[{"given":"Sushma","family":"Sharma","sequence":"first","affiliation":[{"name":"CSIR-Institute of Microbial Technology, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00a0","family":"Alfatah","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Microbial Technology, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay K.","family":"Bari","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Microbial Technology, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashpal","family":"Rawal","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Microbial Technology, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjoy","family":"Paul","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Microbial Technology, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ganesan","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Microbial Technology, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis021"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.10.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3314\/jjmm.48.1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/430923"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4419-4431.2004"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2011.00278.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-180-2_29"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1179"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00045-10"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-180-2_25"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2009.06.003"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117280109"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01145-12"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00303-10"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.8.2404-2412.2003"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00423-08"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.9.2717-2724.2003"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.12.4129"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3254"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00238-6"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004697"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/42408"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.14.1.111"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1778-1787.2004"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00861-07"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E08-11-1126"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.10.005"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004762"},{"key":"e_1_3_3_31_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard\u20143rd ed","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. 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