{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:06:04Z","timestamp":1791338764573,"version":"4.3.1"},"reference-count":81,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"ERA-NET Cofund EURONANOMED","award":["2017-178"],"award-info":[{"award-number":["2017-178"]}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2017-SGR-908"],"award-info":[{"award-number":["2017-SGR-908"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["RTI2018-094579-B-I00"],"award-info":[{"award-number":["RTI2018-094579-B-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PCIN-2017-100"],"award-info":[{"award-number":["PCIN-2017-100"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["BIO2016-78310-R"],"award-info":[{"award-number":["BIO2016-78310-R"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,5,21]]},"abstract":"<jats:p>\n            The rapid evolution of resistance in the malaria parasite to every single drug developed against it calls for the urgent identification of new molecular targets. Using a stain specific for the detection of intracellular amyloid deposits in live cells, we have detected the presence of abundant protein aggregates in\n            <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n            blood stages and female gametes cultured\n            <jats:italic>in vitro<\/jats:italic>\n            , in the blood stages of mice infected by\n            <jats:named-content content-type=\"genus-species\">Plasmodium yoelii<\/jats:named-content>\n            , and in the mosquito stages of the murine malaria species\n            <jats:named-content content-type=\"genus-species\">Plasmodium berghei<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.02135-19","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T14:19:48Z","timestamp":1586614788000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Detection of Protein Aggregation in Live\n            <i>Plasmodium<\/i>\n            Parasites"],"prefix":"10.1128","volume":"64","author":[{"given":"Arnau","family":"Biosca","sequence":"first","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Hospital Cl\u00ednic-Universitat de Barcelona, Barcelona, Spain"},{"name":"Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain"},{"name":"Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Bouz\u00f3n-Arn\u00e1iz","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Hospital Cl\u00ednic-Universitat de Barcelona, Barcelona, Spain"},{"name":"Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain"},{"name":"Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lefteris","family":"Spanos","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Siden-Kiamos","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valent\u00edn","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i de Biomedicina, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"},{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Ventura","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i de Biomedicina, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"},{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-9631","authenticated-orcid":false,"given":"Xavier","family":"Fern\u00e0ndez-Busquets","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Hospital Cl\u00ednic-Universitat de Barcelona, Barcelona, Spain"},{"name":"Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain"},{"name":"Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","DOI":"10.30875\/7e6f8c91-en","volume-title":"World malaria report, 2019","author":"World Health Organization","year":"2019","unstructured":"World Health Organization. 2019. World malaria report, 2019. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14412"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3077"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1529"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01097"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03481"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(03)01023-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2004.05.016"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2006.08.011"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2006.03.023"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.051471205"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.05.013"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-045115"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.050"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001451"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msn122"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7401034"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.041"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.008"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5275.622"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003488"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2015.00034"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2306"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.01.009"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01737"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119366109"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004013"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201400291"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4508"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798358"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.340513"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201801606"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019876"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001032"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-2-18"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b00417"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2009.03.012"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20764"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/psc.910"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2014.06.002"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-4165(03)00101-6"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1139\/o03-009"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00866-13"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13320"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02391"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi700411k"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06221-1"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260403"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13269"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/416507a"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400348200"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.116"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308249101"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403756101"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.09.052"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.04707004"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04195"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6059"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.9.1107"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.043398"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90279-8"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.6b00643"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404751200"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.01.001"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0035-9203(97)90110-3"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.2307\/3280287"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.198"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087025"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-026-7_2"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03666-14"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2004.00394.x"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2005.09.007"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku989"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu310"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080856"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.O111.014704"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1012"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.05.284"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.485359"},{"key":"e_1_3_3_82_2","first-page":"829","article-title":"Diagnostic utility of red cell flow cytometric analysis","volume":"21","author":"Davis BH","year":"2001","unstructured":"Davis BH. 2001. Diagnostic utility of red cell flow cytometric analysis. Clin Lab Med 21:829\u2013840.","journal-title":"Clin Lab Med"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02135-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02135-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:45:23Z","timestamp":1645479923000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02135-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,21]]},"references-count":81,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,5,21]]}},"alternative-id":["10.1128\/AAC.02135-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.02135-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,21]]},"assertion":[{"value":"2019-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02135-19"}}