{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:40:15Z","timestamp":1782441615666,"version":"3.54.5"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Infections caused by multidrug-resistant\n            <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n            (MDRPA) present a major problem for therapeutic management. We report here our experience with 12 patients with a severe MDRPA infection (6 of which were pneumonia) who received salvage therapy with ceftolozane-tazobactam after inappropriate empirical treatment and\/or suboptimal targeted treatment. Although 10 of the 12 patients (83.3%) experienced septic shock, only 3 patients (25%) died during the follow-up period. Microbiological cure in 7 patients (58.3%) was observed.\n          <\/jats:p>","DOI":"10.1128\/aac.02136-16","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T02:30:41Z","timestamp":1481596241000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Salvage Therapy with Ceftolozane-Tazobactam for Multidrug-Resistant Pseudomonas aeruginosa Infections"],"prefix":"10.1128","volume":"61","author":[{"given":"Juan Jos\u00e9","family":"Cast\u00f3n","sequence":"first","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Hospital Universitario Reina Sof\u00eda-Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica (IMIBIC), C\u00f3rdoba, Spain"},{"name":"Spanish Network for the Research in Infectious Diseases (REIPI RD12\/2015), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"De la Torre","sequence":"additional","affiliation":[{"name":"Service of Anesthesiology and Reanimation, Hospital de Jaen, Jaen, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Ruiz-Camps","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Sorl\u00ed","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital del Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Torres","sequence":"additional","affiliation":[{"name":"Service of Anesthesia and Reanimation, Hospital Universitario Son Espases, Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Torre-Cisneros","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Hospital Universitario Reina Sof\u00eda-Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica (IMIBIC), C\u00f3rdoba, Spain"},{"name":"Spanish Network for the Research in Infectious Diseases (REIPI RD12\/2015), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01645-10"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(03)00245-0"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.03.001"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2192-x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1609"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-016-0944-5"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.04.004"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.07.004"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62220-0"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ097"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-6553(88)90053-3"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks246"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmmcr.0.000025"},{"key":"e_1_3_1_15_2","first-page":"35","article-title":"Triple antibiotic therapy with ceftolozane\/tazobactam, colistin and rifampin for pan-resistant Pseudomonas aeruginosa ventilator-associated pneumonia","volume":"3","author":"Alqaid A","year":"2015","unstructured":"Alqaid A DoughertyCKAhmadS. 2015. Triple antibiotic therapy with ceftolozane\/tazobactam, colistin and rifampin for pan-resistant Pseudomonas aeruginosa ventilator-associated pneumonia. Southwest Respir Crit Care Chron3:35\u201339.","journal-title":"Southwest Respir Crit Care Chron"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02462-13"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02136-16","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02136-16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:45:27Z","timestamp":1645476327000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02136-16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1128\/AAC.02136-16"],"URL":"https:\/\/doi.org\/10.1128\/aac.02136-16","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"2016-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02136-16"}}