{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:16:37Z","timestamp":1784646997945,"version":"3.55.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Practitioner Fellowship","award":["APP1117065"],"award-info":[{"award-number":["APP1117065"]}]},{"name":"Advancing Queensland Clinical Fellowship"},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["2019-05908"],"award-info":[{"award-number":["2019-05908"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1099452"],"award-info":[{"award-number":["APP1099452"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP119786"],"award-info":[{"award-number":["APP119786"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:p>\n            Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two\n            <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n            isolates. Following initial kill of \u223c 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 10\n            <jats:sup>8<\/jats:sup>\n            \u2013 10\n            <jats:sup>10<\/jats:sup>\n            CFU\/mL at 120 h.\n          <\/jats:p>","DOI":"10.1128\/aac.02140-21","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T13:00:26Z","timestamp":1649336426000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates"],"prefix":"10.1128","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-644X","authenticated-orcid":true,"given":"Natalija","family":"Karabasevic","sequence":"first","affiliation":[{"name":"Medical Programme, Faculty of Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6218-435X","authenticated-orcid":true,"given":"Jason A.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia"},{"name":"Royal Brisbane and Women\u2019s Hospital, Brisbane, Queensland, Australia"},{"name":"Division of Anaesthesiology Critical Care Emergency and Pain Medicine, N\u00eemes University Hospital, University of Montpellier, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Stronach","sequence":"additional","affiliation":[{"name":"Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiyuri","family":"Naicker","sequence":"additional","affiliation":[{"name":"Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Wallis","sequence":"additional","affiliation":[{"name":"The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Sj\u00f6vall","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Perioperative Medicine, Skane University Hospital, Malm\u00f6, Sweden"},{"name":"Mitochondrial Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4061-2063","authenticated-orcid":true,"given":"Fekade","family":"Sime","sequence":"additional","affiliation":[{"name":"Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4683-6"},{"key":"e_1_3_2_3_2","first-page":"288","volume-title":"Medical microbiology","author":"Murray PR","year":"2013","unstructured":"Murray PR, Rosenthal KS, Pfaller MA. 2013. Medical microbiology, p 288\u2013295, 7 ed. Elsevier\/Saunders, Philadelphia.","edition":"7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.11.013"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.31.6.598"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2019.10.020"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2003.00790.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.3.677"},{"key":"e_1_3_2_9_2","first-page":"101","article-title":"The hollow fiber infection model: principles and practice","volume":"1","author":"Cadwell JJ","year":"2015","unstructured":"Cadwell JJ. 2015. The hollow fiber infection model: principles and practice. Adv Antibiotics Antibodies 1:101.","journal-title":"Adv Antibiotics Antibodies"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx330"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz069"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00689-07"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01150-18"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540110027222"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.02.019"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.9.1847"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2009.02.003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00464-08"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy825"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2014.899279"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01108-9"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.11.013"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx315"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5833"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.02140-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.02140-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T13:08:11Z","timestamp":1652792891000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.02140-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,17]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,17]]}},"alternative-id":["10.1128\/aac.02140-21"],"URL":"https:\/\/doi.org\/10.1128\/aac.02140-21","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,17]]},"assertion":[{"value":"2021-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02140-21"}}