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Our study investigated the molecular epidemiology and antibiotic resistance features of 28 consecutive carbapenem-resistant clinical isolates of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>\n            collected throughout Sweden in 2012 and 2013. The isolates mainly belonged to clonal complexes (CCs) with an extensive international distribution, such as CC2 (\n            <jats:italic>n<\/jats:italic>\n            = 16) and CC25 (\n            <jats:italic>n<\/jats:italic>\n            = 7). Resistance to carbapenems was related to\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>OXA-23<\/jats:sub>\n            (20 isolates),\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>OXA-24\/40-like<\/jats:sub>\n            (6 isolates),\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>OXA-467<\/jats:sub>\n            (1 isolate), and IS\n            <jats:italic>Aba1-bla<\/jats:italic>\n            <jats:sub>OXA-69<\/jats:sub>\n            (1 isolate). Ceftazidime resistance was associated with\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>PER-7<\/jats:sub>\n            in the CC25 isolates. Two classical point mutations were responsible for resistance to quinolones in all the isolates. Isolates with high levels of resistance to aminoglycosides carried the 16S rRNA methylase\n            <jats:italic>armA<\/jats:italic>\n            gene. The isolates also carried a variety of genes encoding aminoglycoside-modifying enzymes. Several novel structures involved in aminoglycoside resistance were identified, including Tn\n            <jats:italic>6279<\/jats:italic>\n            , \u0394Tn\n            <jats:italic>6279<\/jats:italic>\n            , Ab-ST3-\n            <jats:italic>aadB<\/jats:italic>\n            , and different assemblies of Tn\n            <jats:italic>6020<\/jats:italic>\n            and Tn\n            <jats:italic>aphA6<\/jats:italic>\n            . Importantly, a number of circular forms related to the IS\n            <jats:italic>26<\/jats:italic>\n            or IS\n            <jats:italic>Aba125<\/jats:italic>\n            composite transposons were detected. The frequent occurrence of these circular forms in the populations of several isolates indicates a potential role of these circular forms in the dissemination of antibiotic resistance genes.\n          <\/jats:p>","DOI":"10.1128\/aac.02143-15","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T03:49:28Z","timestamp":1452570568000},"page":"1801-1818","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":63,"title":["Novel Aminoglycoside Resistance Transposons and Transposon-Derived Circular Forms Detected in Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates"],"prefix":"10.1128","volume":"60","author":[{"given":"Nabil","family":"Karah","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden, and Ume\u00e5 Centre for Microbial Research, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmay Kumar","family":"Dwibedi","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Laboratory for Molecular Infection Medicine Sweden, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Sj\u00f6str\u00f6m","sequence":"additional","affiliation":[{"name":"Unit for Antibiotic Resistance and Respiratory Bacterial Infections, Public Health Agency of Sweden, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Edquist","sequence":"additional","affiliation":[{"name":"Unit for Antibiotic Resistance and Respiratory Bacterial Infections, Public Health Agency of Sweden, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0548-5943","authenticated-orcid":false,"given":"Anders","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Laboratory for Molecular Infection Medicine Sweden, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Nyunt","family":"Wai","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden, and Ume\u00e5 Centre for Microbial Research, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernt Eric","family":"Uhlin","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden, and Ume\u00e5 Centre for Microbial Research, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1789"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2012.06.001"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010034"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-07"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01456.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks345"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.45716-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr163"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01407-08"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00560-07"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/518605"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.02.010"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/39.6.757"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2011.0089"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.3.827-832.2006"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01021-06"},{"key":"e_1_3_3_18_2","volume-title":"Performance standards for antimicrobial susceptibility testing; 24th informational supplement","author":"Clinical and Laboratory Standards Institute","year":"2014","unstructured":"Clinical and Laboratory Standards Institute. 2014. 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