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CMCdG\u2019s\n            <jats:italic>in vitro<\/jats:italic>\n            activity was determined using quantitative PCR and Southern blotting assays, and its cytotoxicity was determined with a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay, while its\n            <jats:italic>in vivo<\/jats:italic>\n            activity and safety were determined in human liver-chimeric mice infected with wild-type HBV genotype Ce (HBV\n            <jats:sub>WT<\/jats:sub>\n            <jats:sup>Ce<\/jats:sup>\n            ) and an entecavir (ETV)-resistant HBV variant containing the amino acid substitutions L180M, S202G, and M204V (HBV\n            <jats:sub>ETV-R<\/jats:sub>\n            <jats:sup>L180M\/S202G\/M204V<\/jats:sup>\n            ).\n          <\/jats:p>","DOI":"10.1128\/aac.02143-18","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T07:51:51Z","timestamp":1547797911000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus"],"prefix":"10.1128","volume":"63","author":[{"given":"Nobuyo","family":"Higashi-Kuwata","sequence":"first","affiliation":[{"name":"Department of Refractory Viral Infections, National Center for Global Health &amp; 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