{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:04:13Z","timestamp":1790136253987,"version":"4.0.1"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            MK-3118 is as an orally active new antifungal in the early stage of clinical development that inhibits the biosynthesis of \u03b2-(1,3)-glucan. We evaluated the\n            <jats:italic>in vitro<\/jats:italic>\n            activity of this compound against wild-type and echinocandin-resistant (ER) isolates containing mutations in the\n            <jats:italic>FKS<\/jats:italic>\n            gene(s) of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida<\/jats:named-content>\n            spp. and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aspergillus<\/jats:named-content>\n            spp. MK-3118 demonstrated enhanced efficacy for most\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. albicans<\/jats:named-content>\n            and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. glabrata<\/jats:named-content>\n            ER isolates relative to caspofungin, with decreased MICs and half-maximal inhibitory concentrations (IC\n            <jats:sub>50<\/jats:sub>\n            s).\n          <\/jats:p>","DOI":"10.1128\/aac.02145-13","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T02:55:08Z","timestamp":1386644108000},"page":"1248-1251","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":119,"title":["Enfumafungin Derivative MK-3118 Shows Increased\n            <i>In Vitro<\/i>\n            Potency against Clinical Echinocandin-Resistant Candida Species and Aspergillus Species Isolates"],"prefix":"10.1128","volume":"58","author":[{"given":"Cristina","family":"Jim\u00e9nez-Ortigosa","sequence":"first","affiliation":[{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmaja","family":"Paderu","sequence":"additional","affiliation":[{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary R.","family":"Motyl","sequence":"additional","affiliation":[{"name":"Merck, Sharp &amp; Dohme Corp., Kenilworth, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Perlin","sequence":"additional","affiliation":[{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/596757"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14472-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2007.04.002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.2.368-377.2000"},{"key":"e_1_3_2_6_2","volume-title":"Abstr. 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Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard. Clinical and Laboratory Standards Institute document M27-A3, 3rd ed, vol 28. National Committee for Clinical Laboratory Standards, Wayne, PA.","edition":"3"},{"key":"e_1_3_2_12_2","volume-title":"Clinical and Laboratory Standards Institute document M38-A2","author":"National Committee for Clinical Laboratory Standards","year":"2008","unstructured":"National Committee for Clinical Laboratory Standards. 2008. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard. Clinical and Laboratory Standards Institute document M38-A2, 2nd ed, vol 28. 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