{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:56:34Z","timestamp":1790700994321,"version":"4.1.0"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In this study, using the Hain GenoType MTBDR\n            <jats:italic>sl<\/jats:italic>\n            assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in\n            <jats:italic>gyrA<\/jats:italic>\n            in\n            <jats:named-content content-type=\"genus-species\">Mycobacterium tuberculosis<\/jats:named-content>\n            result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations. Although these mutations are likely rare globally, they occur in approximately 7% of multidrug-resistant tuberculosis strains in some settings.\n          <\/jats:p>","DOI":"10.1128\/aac.02169-16","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T02:50:39Z","timestamp":1485831039000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Some Synonymous and Nonsynonymous\n            <i>gyrA<\/i>\n            Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDR\n            <i>sl<\/i>\n            Assays"],"prefix":"10.1128","volume":"61","author":[{"given":"Adebisi","family":"Ajileye","sequence":"first","affiliation":[{"name":"Public Health England West Midlands Public Health Laboratory, Heartlands Hospital, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataly","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Bacteriology and Mycobacteria Unit, Corporaci\u00f3n Para Investigaciones Biol\u00f3gicas, Medell\u00edn, Colombia"},{"name":"Universidad Pontificia Bolivariana, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Merker","sequence":"additional","affiliation":[{"name":"Division of Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany"},{"name":"German Center for Infection Research (DZIF), Partnersite Hamburg-L\u00fcbeck-Borstel, Borstel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Walker","sequence":"additional","affiliation":[{"name":"Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suriya","family":"Akter","sequence":"additional","affiliation":[{"name":"Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Brown","sequence":"additional","affiliation":[{"name":"Public Health England West Midlands Public Health Laboratory, Heartlands Hospital, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danesh","family":"Moradigaravand","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Division of Medical Microbiology, Link\u00f6ping University, Link\u00f6ping, Sweden"},{"name":"Department of Clinical Microbiology and Infectious Diseases, Kalmar County Hospital, Kalmar, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6nke","family":"Andres","sequence":"additional","affiliation":[{"name":"Division of Mycobacteriology, National Tuberculosis Reference Laboratory, Research Center Borstel, Borstel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Schleusener","sequence":"additional","affiliation":[{"name":"Division of Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaheed V.","family":"Omar","sequence":"additional","affiliation":[{"name":"Centre for Tuberculosis, National Institute for Communicable Diseases, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Coll","sequence":"additional","affiliation":[{"name":"London School of Hygiene &amp; 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