{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:49:46Z","timestamp":1790138986712,"version":"4.0.1"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2015R1A2A1A01003959"],"award-info":[{"award-number":["NRF-2015R1A2A1A01003959"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI15C2778"],"award-info":[{"award-number":["HI15C2778"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Macrolide antibiotics are cornerstones in the treatment of\n            <jats:named-content content-type=\"genus-species\">Mycobacterium massiliense<\/jats:named-content>\n            lung disease. Despite the emergence of resistance, limited data on macrolide-resistant\n            <jats:italic>M<\/jats:italic>\n            .\n            <jats:named-content content-type=\"genus-species\">massiliense<\/jats:named-content>\n            lung disease are available. This study evaluated the clinical features and treatment outcomes of patients and the molecular characteristics of macrolide-resistant\n            <jats:italic>M<\/jats:italic>\n            .\n            <jats:named-content content-type=\"genus-species\">massiliense<\/jats:named-content>\n            isolates. We performed a retrospective review of medical records and genetic analyses of clinical isolates from 15 patients who had macrolide-resistant\n            <jats:italic>M<\/jats:italic>\n            .\n            <jats:named-content content-type=\"genus-species\">massiliense<\/jats:named-content>\n            lung disease between September 2005 and February 2015. Nine patients (60%) had the nodular bronchiectatic form of the disease, and six (40%) had the fibrocavitary form. Before the detection of macrolide resistance, three patients (20%) were treated with macrolide monotherapy, four (27%) with therapy for presumed\n            <jats:named-content content-type=\"genus-species\">Mycobacterium avium<\/jats:named-content>\n            complex infections, and eight (53%) with combination antibiotic therapy for\n            <jats:italic>M<\/jats:italic>\n            .\n            <jats:named-content content-type=\"genus-species\">massiliense<\/jats:named-content>\n            lung disease. The median treatment duration after the detection of resistance was 18.7 months (interquartile range, 11.2 to 39.8 months). Treatment outcomes were poor, with a favorable outcome being achieved for only one patient (7%), who underwent surgery in addition to antibiotic therapy. The 1-, 3-, and 5-year mortality rates were 7, 13, and 33%, respectively. Of the 15 clinical isolates, 14 (93%) had point mutations at position 2058 (\n            <jats:italic>n<\/jats:italic>\n            = 9) or 2059 (\n            <jats:italic>n<\/jats:italic>\n            = 5) of the 23S rRNA gene, resulting in macrolide resistance. Our study indicates that treatment outcomes are poor and mortality rates are high after the development of macrolide resistance in patients with\n            <jats:italic>M<\/jats:italic>\n            .\n            <jats:named-content content-type=\"genus-species\">massiliense<\/jats:named-content>\n            lung disease. Thus, preventing the development of macrolide resistance should be a key consideration during treatment.\n          <\/jats:p>","DOI":"10.1128\/aac.02189-16","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T03:20:35Z","timestamp":1479784835000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Clinical Characteristics and Treatment Outcomes of Patients with Macrolide-Resistant Mycobacterium massiliense Lung Disease"],"prefix":"10.1128","volume":"61","author":[{"given":"Hayoung","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care 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