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The SPT class operates via a novel mode of inhibition, which involves Mg\n            <jats:sup>2+<\/jats:sup>\n            -independent stabilization of the DNA cleavage complex with DNA gyrase and is thereby not cross-resistant with other DNA gyrase-inhibiting antibacterials, including fluoroquinolones.\n          <\/jats:p>","DOI":"10.1128\/aac.02192-21","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T16:00:34Z","timestamp":1646928034000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones"],"prefix":"10.1128","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5684-6046","authenticated-orcid":true,"given":"Gregory S.","family":"Basarab","sequence":"first","affiliation":[{"name":"Drug Discovery and 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