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We describe two patients with refractory<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. glabrata<\/jats:named-content>cystitis who failed flucytosine combined with caspofungin with early-acquired high-level resistance to flucytosine due to nonsense mutations in the<jats:italic>FUR1<\/jats:italic>gene. Rapidly acquired flucytosine resistance with microbiological failure should discourage combination of caspofungin and flucytosine during urinary candidiasis.<\/jats:p>","DOI":"10.1128\/aac.02265-15","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T01:35:21Z","timestamp":1446514521000},"page":"662-665","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Acquired Flucytosine Resistance during Combination Therapy with Caspofungin and Flucytosine for Candida glabrata Cystitis"],"prefix":"10.1128","volume":"60","author":[{"given":"Caroline","family":"Charlier","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9, Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, H\u00f4pital Universitaire Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Institut Imagine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"El Sissy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9, Service de Microbiologie Clinique, H\u00f4pital Universitaire Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Bachelier-Bassi","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, INRA, USC2019, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Scemla","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9, Service de Transplantation R\u00e9nale, H\u00f4pital Universitaire Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Quesne","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9, Service de Microbiologie Clinique, H\u00f4pital Universitaire Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Sitterl\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9, Service de Microbiologie Clinique, H\u00f4pital Universitaire Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Legendre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9, Service de Transplantation R\u00e9nale, H\u00f4pital Universitaire Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lortholary","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9, Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, H\u00f4pital Universitaire Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Institut Imagine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Elisabeth","family":"Bougnoux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9, Service de Microbiologie Clinique, H\u00f4pital Universitaire Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"},{"name":"Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, INRA, USC2019, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir112"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14472-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1111\/1469-0691.12039","article-title":"ESCMID guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients","volume":"18","author":"Cornely OA","year":"2012","unstructured":"Cornely OA, Bassetti M, Calandra T, Garbino J, Kullberg BJ, Lortholary O, Meersseman W, Akova M, Arendrup MC, Arikan-Akdagli S, Bille J, Castagnola E, Cuenca-Estrella M, Donnelly JP, Groll AH, Herbrecht R, Hope WW, Jensen HE, Lass-Florl C, Petrikkos G, Richardson MD, Roilides E, Verweij PE, Viscoli C, Ullmann AJ. 2012. 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