{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:32:36Z","timestamp":1763987556734},"reference-count":23,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Genetic determinants of a\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            -positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX_NDM1 and pKOX-R1, were identified for the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella oxytoca<\/jats:named-content>\n            strain E718. Sequence annotation revealed a\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            gene in pKOX_NDM1 and two extended-spectrum \u03b2-lactamase producers (\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-3<\/jats:sub>\n            and\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>SHV-12<\/jats:sub>\n            ) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrug-resistant bacterial infections and the potential danger of emerging resistant enterobacteria.\n          <\/jats:p>","DOI":"10.1128\/aac.02266-12","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T04:02:11Z","timestamp":1370923331000},"page":"4072-4076","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":57,"title":["Complete Sequences of Two Plasmids in a\n            <i>bla<\/i>\n            <sub>NDM-1<\/sub>\n            -Positive Klebsiella oxytoca Isolate from Taiwan"],"prefix":"10.1128","volume":"57","author":[{"given":"Tzu-Wen","family":"Huang","sequence":"first","affiliation":[{"name":"Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jann-Tay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsai-Ling","family":"Lauderdale","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsai-Lien","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui-Fen","family":"Lai","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases and Vaccinology, National Health Research 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