{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:22:44Z","timestamp":1792732964100,"version":"4.5.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            This study addresses the effects of micafungin, caspofungin, and anidulafungin against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida albicans<\/jats:named-content>\n            biofilms developed in a subcutaneous catheter rat model system. Doses of 5, 10, and 30 mg\/kg (of body weight)\/day (the last only for micafungin) were given intravenously for 5, 7, and 10 days. All three echinocandins caused a significant reduction of the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida<\/jats:named-content>\n            cell numbers on the implanted catheters and are thus promising for the treatment of biofilm-related infections.\n          <\/jats:p>","DOI":"10.1128\/aac.02288-12","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T01:16:33Z","timestamp":1360718193000},"page":"2365-2368","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Activities of Systemically Administered Echinocandins against\n            <i>In Vivo<\/i>\n            Mature Candida albicans Biofilms Developed in a Rat Subcutaneous Model"],"prefix":"10.1128","volume":"57","author":[{"given":"So\u0148a","family":"Kuchar\u00edkov\u00e1","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology, VIB, K.U. Leuven, Leuven, Belgium"},{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, K.U. Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, VIB, K.U. Leuven, Leuven, Belgium"},{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, K.U. Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Spriet","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Research Centre for Clinical Pharmacy, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Maertens","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Van Dijck","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, VIB, K.U. Leuven, Leuven, Belgium"},{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, K.U. Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Lagrou","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, K.U. Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/596757"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1773-1780.2002"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.11.3591-3596.2002"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/506452"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp242"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00697-10"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00480-10"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00328721"},{"key":"e_1_3_3_10_2","unstructured":"CLSI. 2008. Reference method for broth dilution antifungal susceptibility testing of yeast; approved standard\u2014third edition; CLSI document M27-A3. 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