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Based on 147 NCBI entries for SHV alleles,\n            <jats:italic>in silico<\/jats:italic>\n            mathematical models predicted 5 positions as relevant for the \u03b2-lactamase inhibitor (BLI)-resistant (2br) phenotype, 12 positions as relevant for the extended-spectrum BL (ESBL) (2be) phenotype, and 2 positions as related solely to the narrow-spectrum (2b) phenotype. These positions and six additional positions described in other studies (including one promoter mutation) were systematically substituted and investigated for their substrate specificities in a BL-free\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            background, representing, to our knowledge, the most comprehensive substrate and substitution analysis for SHV alleles to date.\n          <\/jats:p>","DOI":"10.1128\/aac.02293-19","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T18:01:16Z","timestamp":1586887276000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["A Genotype-Phenotype Correlation Study of SHV \u03b2-Lactamases Offers New Insight into SHV Resistance 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