{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:07:49Z","timestamp":1787065669377,"version":"build-2736575974"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Identification of a novel class of anti-\n Burkholderia<\/jats:named-content>\n compounds is key in addressing antimicrobial resistance to current therapies as well as naturally occurring resistance. The FabI enoyl-ACP reductase in\n Burkholderia<\/jats:named-content>\n is an underexploited target that presents an opportunity for development of a new class of inhibitors. A library of substituted diphenyl ethers was used to identify FabI1-specific inhibitors for assessment in\n Burkholderia pseudomallei ex vivo<\/jats:named-content>\n and murine efficacy models. Active FabI1 inhibitors were identified in a two-stage format consisting of percent inhibition screening and MIC determination by the broth microdilution method. Each compound was evaluated against the\n B. pseudomallei<\/jats:named-content>\n 1026b (efflux-proficient) and Bp400 (efflux-compromised) strains.\n In vitro<\/jats:italic>\n screening identified candidate substituted diphenyl ethers that exhibited MICs of less than 1 \u03bcg\/ml, and enzyme kinetic assays were used to assess potency and specificity against the FabI1 enzyme. These compounds demonstrated activity in a\n Burkholderia ex vivo<\/jats:named-content>\n efficacy model, and two demonstrated efficacy in an acute\n B. pseudomallei<\/jats:named-content>\n mouse infection model. This work establishes substituted diphenyl ethers as a suitable platform for development of novel anti-\n Burkholderia<\/jats:named-content>\n compounds that can be used for treatment of melioidosis.\n <\/jats:p>","DOI":"10.1128\/aac.02296-13","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T21:28:14Z","timestamp":1388438894000},"page":"1646-1651","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Substituted Diphenyl Ethers as a Novel Chemotherapeutic Platform against Burkholderia pseudomallei"],"prefix":"10.1128","volume":"58","author":[{"given":"Jason E.","family":"Cummings","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Beaupre","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Knudson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Neckles","sequence":"additional","affiliation":[{"name":"Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Khanna","sequence":"additional","affiliation":[{"name":"Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal R.","family":"Bommineni","sequence":"additional","affiliation":[{"name":"Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily A.","family":"Trunck","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert P.","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Tonge","sequence":"additional","affiliation":[{"name":"Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Slayden","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.2.383-416.2005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1385"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2009.00189.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000244046.31135.b3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S35529"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652006000100001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1407.071501"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(08)70002-6"},{"key":"e_1_3_3_10_2","first-page":"1438","article-title":"Melioidosis\u2014a report from Pondicherry, South 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