{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:52:53Z","timestamp":1792633973128,"version":"4.5.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1K08AI119157-04"],"award-info":[{"award-number":["1K08AI119157-04"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,5,18]]},"abstract":"<jats:p>Current growth-based antibiotic susceptibility testing (AST) is too slow to guide early therapy. We previously developed a diagnostic approach that quantifies antibiotic-induced transcriptional signatures to distinguish susceptible from resistant isolates, providing phenotypic AST 24 to 36 h faster than current methods.<\/jats:p>","DOI":"10.1128\/aac.02296-20","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T08:33:05Z","timestamp":1617784385000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Core Antibiotic-Induced Transcriptional Signatures Reflect Susceptibility to All Members of an Antibiotic Class"],"prefix":"10.1128","volume":"65","author":[{"given":"Melanie A.","family":"Martinsen","sequence":"first","affiliation":[{"name":"Infectious Disease and Microbiome Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Jaramillo Cartagena","sequence":"additional","affiliation":[{"name":"Infectious Disease and Microbiome Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6955-5088","authenticated-orcid":true,"given":"Roby P.","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Infectious Disease and Microbiome Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA"},{"name":"Infectious Diseases Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Antimicrobial resistance. Tackling a crisis for the health and wealth of nations.","author":"O'Neill J","year":"2014","unstructured":"O'Neill J. 2014. Antimicrobial resistance. Tackling a crisis for the health and wealth of nations. The Wellcome Trust, London, United Kingdom."},{"key":"e_1_3_3_3_2","volume-title":"Antimicrobial resistance: global report on surveillance.","author":"WHO","year":"2014","unstructured":"WHO. 2014. Antimicrobial resistance: global report on surveillance. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_3_4_2","volume-title":"Global antimicrobial resistance surveillance system (GLASS) report: early implementation 2020.","author":"WHO","year":"2020","unstructured":"WHO. 2020. Global antimicrobial resistance surveillance system (GLASS) report: early implementation 2020. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01041-09"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy378"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.521"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit578"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.103"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.2899"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(20)30477-1"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0650-9"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1385"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02771-15"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.11.012"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01166-17"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35916-0"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01207-19"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406796200"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03566-X"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.8.2838-2844.2004"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00433-18"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.28.5.601"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/11.3.361"},{"key":"e_1_3_3_25_2","volume-title":"Performance standards for antimicrobial susceptibility testing.","author":"CLSI","year":"2020","unstructured":"CLSI. 2020. Performance standards for antimicrobial susceptibility testing. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa345"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119540109"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01762-09"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01413-16"},{"key":"e_1_3_3_30_2","volume-title":"Breakpoint tables for interpretation of MICs and zone diameters. Version 10.0.","author":"EUCAST","year":"2020","unstructured":"EUCAST. 2020. Breakpoint tables for interpretation of MICs and zone diameters. Version 10.0. The European Committee on Antimicrobial Susceptibility Testing, Vaxjo, Sweden."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02296-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02296-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:29:07Z","timestamp":1645468147000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02296-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,5,18]]}},"alternative-id":["10.1128\/AAC.02296-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.02296-20","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.739924412.793585103","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.10.29.359208","asserted-by":"object"}]},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,18]]},"assertion":[{"value":"2020-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02296-20"}}