{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:51:48Z","timestamp":1790077908364,"version":"4.0.1"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We studied the\n            <jats:italic>in vitro<\/jats:italic>\n            and\n            <jats:italic>in vivo<\/jats:italic>\n            efficacies of the investigational drug isavuconazole against mucormycosis due to\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Rhizopus delemar<\/jats:named-content>\n            . Isavuconazole was effective, with MIC and minimal fungicidal concentration (MFC) values ranging between 0.125 and 1.00 \u03bcg\/ml. A high dose of isavuconazole prolonged the survival time and lowered the tissue fungal burden of cyclophosphamide\/cortisone acetate-treated mice infected with\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">R. delemar<\/jats:named-content>\n            and was as effective as a high-dose liposomal amphotericin B treatment. These results support the further development of this azole against mucormycosis.\n          <\/jats:p>","DOI":"10.1128\/aac.02301-13","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T04:05:07Z","timestamp":1391486707000},"page":"2450-2453","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":68,"title":["Isavuconazole Therapy Protects Immunosuppressed Mice from Mucormycosis"],"prefix":"10.1128","volume":"58","author":[{"given":"Guanpingsheng","family":"Luo","sequence":"first","affiliation":[{"name":"The Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, and St. John's Cardiovascular Research Center, Torrance, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teclegiorgis","family":"Gebremariam","sequence":"additional","affiliation":[{"name":"The Division of Infectious 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