{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:12:47Z","timestamp":1778670767970,"version":"3.51.4"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Our recent report of dihydroartemisinin-piperaquine failure to treat\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n            infections in Cambodia adds new urgency to the search for alternative treatments. Despite dihydroartemisinin-piperaquine failure, and higher piperaquine 50% inhibitory concentrations (IC\n            <jats:sub>50<\/jats:sub>\n            s) following reanalysis than those previously reported,\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. falciparum<\/jats:named-content>\n            remained sensitive to atovaquone (ATQ)\n            <jats:italic>in vitro<\/jats:italic>\n            . There were no point mutations in the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. falciparum<\/jats:named-content>\n            cytochrome\n            <jats:italic>b<\/jats:italic>\n            ATQ resistance gene. Mefloquine, artemisinin, chloroquine, and quinine IC\n            <jats:sub>50<\/jats:sub>\n            s remained comparable to those from other recent reports. Atovaquone-proguanil may be a useful stopgap but remains susceptible to developing resistance when used as blood-stage therapy.\n          <\/jats:p>","DOI":"10.1128\/aac.02302-15","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T03:23:15Z","timestamp":1451359395000},"page":"1896-1898","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Atovaquone-Proguanil Remains a Potential Stopgap Therapy for Multidrug-Resistant Plasmodium falciparum in Areas along the Thai-Cambodian Border"],"prefix":"10.1128","volume":"60","author":[{"given":"David L.","family":"Saunders","sequence":"first","affiliation":[{"name":"U.S. Army Medical Component-Armed Forces Research Institute for Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suwanna","family":"Chaorattanakawee","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Component-Armed Forces Research Institute for Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panita","family":"Gosi","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Component-Armed Forces Research Institute for Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Lanteri","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Component-Armed Forces Research Institute for Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sok","family":"Somethy","sequence":"additional","affiliation":[{"name":"Royal Cambodian Armed Forces, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Worachet","family":"Kuntawunginn","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Component-Armed Forces Research Institute for Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mali","family":"Ittiverakul","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Component-Armed Forces Research Institute for Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soklyda","family":"Chann","sequence":"additional","affiliation":[{"name":"USAMC-AFRIMS, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie","family":"Gregory","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Component-Armed Forces Research Institute for Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Char Meng","family":"Chuor","sequence":"additional","affiliation":[{"name":"National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satharath","family":"Prom","sequence":"additional","affiliation":[{"name":"Royal Cambodian Armed Forces, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele D.","family":"Spring","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Component-Armed Forces Research Institute for Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanthap","family":"Lon","sequence":"additional","affiliation":[{"name":"USAMC-AFRIMS, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0805011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093138"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1403007"},{"key":"e_1_3_2_5_2","unstructured":"World Health Organization. 2012. 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