{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:22:57Z","timestamp":1759936977970,"version":"3.41.2"},"reference-count":9,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100008968","name":"National Research Council Sri Lanka","doi-asserted-by":"publisher","award":["NRC-12-077"],"award-info":[{"award-number":["NRC-12-077"]}],"id":[{"id":"10.13039\/100008968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The aim of this study was to assess the inflammatory cytokine response and possible association with antimicrobial treatment with penicillin, ceftriaxone, and doxycycline in acute leptospirosis. In the early acute stage, interleukin-10 (IL-10) levels were higher in mild cases than in severe cases (\n            <jats:italic>P<\/jats:italic>\n            = 0.01). IL-6 and IL-8 levels were low in patients who received &gt;5 antimicrobial doses (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01). IL-8 levels were negatively correlated with the number of ceftriaxone doses administered (\n            <jats:italic>r<\/jats:italic>\n            = \u22120.315;\n            <jats:italic>P<\/jats:italic>\n            = 0.031). Further studies are needed to evaluate the possible downregulation of proinflammatory cytokines by ceftriaxone in leptospirosis.\n          <\/jats:p>","DOI":"10.1128\/aac.02312-17","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T09:50:27Z","timestamp":1520329827000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Antimicrobial Agents on Inflammatory Cytokines in Acute Leptospirosis"],"prefix":"10.1128","volume":"62","author":[{"given":"Narmada","family":"Fernando","sequence":"first","affiliation":[{"name":"Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiva","family":"de Silva","sequence":"additional","affiliation":[{"name":"Department of Immunology, Medical Research Institute, Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiroma M.","family":"Handunnetti","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilani","family":"Karunanayake","sequence":"additional","affiliation":[{"name":"National Leptospirosis Reference Laboratory, Medical Research Institute, Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nipun Lakshitha","family":"De Silva","sequence":"additional","affiliation":[{"name":"Tropical Medicine Research Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Janaka","family":"de Silva","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senaka","family":"Rajapakse","sequence":"additional","affiliation":[{"name":"Tropical Medicine Research Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Premawansa","sequence":"additional","affiliation":[{"name":"Faculty of Science, University of Colombo, Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trv095"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002457"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156085"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000453"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-10-52"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1179\/2047773212Y.0000000069"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.6.921"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3630-3633.2003"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.04.011"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02312-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02312-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:16:37Z","timestamp":1645478197000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02312-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1128\/AAC.02312-17"],"URL":"https:\/\/doi.org\/10.1128\/aac.02312-17","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"2017-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02312-17"}}