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New therapies are urgently needed. PBT2 is an ionophore that disrupts metal homeostasis. PBT2 administered with zinc is shown to reverse resistance to antibiotics in several bacterial pathogens. Here we show that both\n            <jats:named-content content-type=\"genus-species\">N. meningitidis<\/jats:named-content>\n            and MDR\n            <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n            are sensitive to killing by PBT2 alone. PBT2 is, thus, a candidate therapeutic for MDR\n            <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n            infections.\n          <\/jats:p>","DOI":"10.1128\/aac.02318-21","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T13:00:23Z","timestamp":1660827623000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Repurposing the Ionophore, PBT2, for Treatment of Multidrug-Resistant Neisseria gonorrhoeae Infections"],"prefix":"10.1128","volume":"66","author":[{"given":"Freda E.-C.","family":"Jen","sequence":"first","affiliation":[{"name":"Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3568-0344","authenticated-orcid":true,"given":"Jennifer L.","family":"Edwards","sequence":"additional","affiliation":[{"name":"The Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital and The Department of Pediatrics, The Ohio State University, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M.","family":"El-Deeb","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Walker","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-7524","authenticated-orcid":true,"given":"Mark","family":"von Itzstein","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-4684","authenticated-orcid":true,"given":"Michael P.","family":"Jennings","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2693"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32833f0d3e"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1145"},{"key":"e_1_3_3_5_2","unstructured":"WHO. 2019. Sexually transmitted infections fact sheet. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/112323\/WHO_RHR_14.10_eng.pdf;jsessionid=6921B7BF04C72E67C5FBB20256DB72C4?sequence=1."},{"key":"e_1_3_3_6_2","unstructured":"CDC. 2013. Antibiotic resistance threats in the United States. https:\/\/www.cdc.gov\/drugresistance\/threat-report-2013\/pdf\/ar-threats-2013-508.pdf-page=55."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.EI10-0009-2015"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-019-0528-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70262-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.0c02754"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02391-18"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb3791"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab291"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00307"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp098"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw288"},{"key":"e_1_3_3_17_2","volume-title":"Performance standards for antimicrobial susceptibility testing","author":"CLSI","year":"2022","unstructured":"CLSI. 2022. Performance standards for antimicrobial susceptibility testing, 32nd Edition. Clinical and Laboratory Standards Institute. Berwyn, PA.","edition":"32"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/MRA.00283-20"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05478.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.12.132"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2009.12.001"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05079.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.11.3713-3720.2005"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03046-19"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6924a2"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70167-4"},{"key":"e_1_3_3_27_2","unstructured":"Limited PB. 2014. Absorption metabolism and excretion study of [14C]PBT2 and absolute bioavailability of PBT2 on 2014. https:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT02249728."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.02318-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.02318-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T13:16:01Z","timestamp":1663679761000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.02318-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,20]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,20]]}},"alternative-id":["10.1128\/aac.02318-21"],"URL":"https:\/\/doi.org\/10.1128\/aac.02318-21","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,20]]},"assertion":[{"value":"2021-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02318-21"}}