{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:13:24Z","timestamp":1769678004985,"version":"3.49.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100008799","name":"Gilead Foundation","doi-asserted-by":"publisher","award":["IA356007"],"award-info":[{"award-number":["IA356007"]}],"id":[{"id":"10.13039\/100008799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n            In sub-Saharan Africa (SSA), gentamicin is commonly used for severe infections in non-intensive-care-unit (ICU) settings, but pharmacokinetic and pharmacodynamic data for this specific population are lacking. We performed a population pharmacokinetic study in an adult Mozambican non-ICU hospital population treated with gentamicin (\n            <jats:italic>n<\/jats:italic>\n            \u2009=\u200948) and developed a pharmacokinetic model using nonlinear mixed-effects modeling.\n          <\/jats:p>","DOI":"10.1128\/aac.02328-18","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T11:51:22Z","timestamp":1548676282000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Population Pharmacokinetics with Monte Carlo Simulations of Gentamicin in a Population of Severely Ill Adult Patients from Sub-Saharan Africa"],"prefix":"10.1128","volume":"63","author":[{"given":"Jeannet C.","family":"Bos","sequence":"first","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of Internal Medicine, Division of Infectious Diseases, Amsterdam, the Netherlands"},{"name":"Catholic University of Mozambique (UCM), Research Center for Infectious Diseases of the Faculty of Health Sciences (CIDI), Beira, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan M.","family":"Prins","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of Internal Medicine, Division of Infectious Diseases, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mabor C.","family":"Mist\u00edcio","sequence":"additional","affiliation":[{"name":"Catholic University of Mozambique (UCM), Research Center for Infectious Diseases of the Faculty of Health Sciences (CIDI), Beira, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginto","family":"Nunguiane","sequence":"additional","affiliation":[{"name":"Catholic University of Mozambique (UCM), Research Center for Infectious Diseases of the Faculty of Health Sciences (CIDI), Beira, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia N.","family":"Lang","sequence":"additional","affiliation":[{"name":"Catholic University of Mozambique (UCM), Research Center for Infectious Diseases of the Faculty of Health Sciences (CIDI), Beira, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 C.","family":"Beir\u00e3o","sequence":"additional","affiliation":[{"name":"Catholic University of Mozambique (UCM), Research Center for Infectious Diseases of the Faculty of Health Sciences (CIDI), Beira, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron A. A.","family":"Math\u00f4t","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of Hospital Pharmacy, Division of Clinical Pharmacology, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinier M.","family":"van Hest","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of Hospital Pharmacy, Division of Clinical Pharmacology, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(15)00137-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002269"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-015-0753-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2016.1172209"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70036-2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky071"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix961"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-008-9094-4"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016215116835"},{"key":"e_1_3_3_12_2","unstructured":"Minist\u00e9rio da Sa\u00fade da Republica de Mo\u00e7ambique. 2007. Formul\u00e1rio nacional de medicamentos. 5a ed. http:\/\/apps.who.int\/medicinedocs\/en\/d\/Js19267pt\/."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.1.93"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.3.623"},{"key":"e_1_3_3_15_2","unstructured":"NVZA. 2018. TDM monografie\u00ebn. http:\/\/tdm-monografie.org\/monografie\/gentamicine."},{"key":"e_1_3_3_16_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2018. Breakpoint tables for interpretation of MICs and zone diameters version 8.1. http:\/\/www.eucast.or\/clinical_breakpoints\/."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.7196\/samj.5941"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4536905"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0392"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw461"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.10.022"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02328-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02328-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:43:19Z","timestamp":1645479799000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02328-18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1128\/AAC.02328-18"],"URL":"https:\/\/doi.org\/10.1128\/aac.02328-18","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2018-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02328-18"}}