{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:21:05Z","timestamp":1791314465246,"version":"4.3.1"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Daptomycin is inactivated by pulmonary surfactant, but its effectiveness in hematogenous pulmonary infection has been poorly studied. The potential therapeutic application was evaluated in a methicillin-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n            (MRSA) hematogenous pulmonary infection mouse model. Compared with control results, daptomycin improved survival (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001) and decreased the number of abscesses and bacteria in the lungs (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01). Daptomycin may be an effective therapeutic option for MRSA hematogenous pulmonary infection.\n          <\/jats:p>","DOI":"10.1128\/aac.02331-12","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T07:06:07Z","timestamp":1363676767000},"page":"2841-2844","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["<i>In Vivo<\/i>\n            Efficacy of Daptomycin against Methicillin-Resistant Staphylococcus aureus in a Mouse Model of Hematogenous Pulmonary Infection"],"prefix":"10.1128","volume":"57","author":[{"given":"Yosuke","family":"Harada","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"},{"name":"Second Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 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