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Here, isavuconazonium sulfate (ISAVUSULF) and fluconazole (FLU) were evaluated in experimental disseminated coccidioidomycosis to characterize drug exposures associated with efficacy. Broth macrodilution was performed on\n            <jats:named-content content-type=\"genus-species\">Coccidioides<\/jats:named-content>\n            isolates to measure minimal effective concentrations (MEC) and minimal fungicidal concentrations (MFC).\n          <\/jats:p>","DOI":"10.1128\/aac.02344-20","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T12:37:11Z","timestamp":1616848631000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy and Associated Drug Exposures of Isavuconazole and Fluconazole in an Experimental Model of Coccidioidomycosis"],"prefix":"10.1128","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4493-4652","authenticated-orcid":true,"given":"Laura L.","family":"Kovanda","sequence":"first","affiliation":[{"name":"Astellas Pharma Global Development, Inc., Northbrook, Illinois, 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Intersci Conf Antimicrob Agents Chemother","author":"Desai A","year":"2014","unstructured":"Desai A, Kovanda L, Kowalski D, Lu Q, Townsend R. 2014. Isavuconazole (ISA) population pharmacokinetic modeling from phase 1 and phase 3 clinical trials and target attainment analysis, abstr A-697. 54th Intersci Conf Antimicrob Agents Chemother, Washington, DC, September 2014."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.34.5.928"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/519937"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.7.1558"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.1.200"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0197-2456(99)00022-7"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1468-6708-3-4"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02344-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02344-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:26:07Z","timestamp":1645485967000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02344-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,5,18]]}},"alternative-id":["10.1128\/AAC.02344-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.02344-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,18]]},"assertion":[{"value":"2020-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02344-20"}}