{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T18:30:07Z","timestamp":1772562607645,"version":"3.50.1"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["UID 87903"],"award-info":[{"award-number":["UID 87903"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\n            <jats:italic>in vitro<\/jats:italic>\n            antifungal activity of aspirin against cryptococcal cells has been reported. However, the unwanted effects of aspirin may limit its clinical application. Conceivably, a derivative of aspirin could overcome this challenge. Toward this end, this study considered the usage of an aspirinate-metal complex, namely, copper acyl salicylate (CAS), as an anti-\n            <jats:named-content content-type=\"genus-species\">Cryptococcus<\/jats:named-content>\n            antifungal agent. Additionally, the study examined the effects of this compound on macrophage function. The\n            <jats:italic>in vitro<\/jats:italic>\n            susceptibility results revealed that cryptococcal cells were vulnerable (in a dose-dependent manner) to CAS, which might have effected growth inhibition by damaging cryptococcal cell membranes. Interestingly, when CAS was used in combination with fluconazole or amphotericin B, synergism was observed. Furthermore, CAS did not negatively affect the growth or metabolic activity of macrophages; rather, it sensitized those immune cells to produce interferon gamma and interleukin 6, which, in turn, might have aided in the phagocytosis of cryptococcal cells. Compared to our aspirin data, CAS was noted to be more effective in killing cryptococcal cells (based on susceptibility results) and less toxic toward macrophages (based on growth inhibition results). Taking these findings together, it is reasonable to conclude that CAS may be a better anti-\n            <jats:named-content content-type=\"genus-species\">Cryptococcus<\/jats:named-content>\n            drug that could deliver better therapeutic outcomes, compared to aspirin.\n          <\/jats:p>","DOI":"10.1128\/aac.02345-17","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T08:17:43Z","timestamp":1526372263000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Copper Acyl Salicylate Has Potential as an Anti-Cryptococcus Antifungal Agent"],"prefix":"10.1128","volume":"62","author":[{"given":"Adepemi O.","family":"Ogundeji","sequence":"first","affiliation":[{"name":"Department of Microbial, Biochemical, and Food Biotechnology, University of the Free State, Bloemfontein, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boitumelo F.","family":"Porotloane","sequence":"additional","affiliation":[{"name":"Department of Microbial, Biochemical, and Food Biotechnology, University of the Free State, Bloemfontein, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina H.","family":"Pohl","sequence":"additional","affiliation":[{"name":"Department of Microbial, Biochemical, and Food Biotechnology, University of the Free State, Bloemfontein, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravin S.","family":"Kendrekar","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Central University of Technology, Bloemfontein, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olihile M.","family":"Sebolai","sequence":"additional","affiliation":[{"name":"Department of Microbial, Biochemical, and Food Biotechnology, University of the Free State, Bloemfontein, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"483","article-title":"Evaluation of conventional and serological methods for rapid diagnosis of cryptococcosis","volume":"127","author":"Saha DC","year":"2008","unstructured":"Saha DC, Xess I, Jain N. 2008. Evaluation of conventional and serological methods for rapid diagnosis of cryptococcosis. Indian J Med Res 127:483\u2013488.","journal-title":"Indian J Med Res"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4102\/sajhivmed.v14i2.82"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12157"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202790"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.012"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2000.12.6.463"},{"key":"e_1_3_2_8_2","volume-title":"Mid-year population estimates","author":"Statistics South Africa","year":"2016","unstructured":"Statistics South Africa. 2016. Mid-year population estimates. 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EUCAST definitive document E.Def 7.3: method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts. EUCAST Copenhagen Denmark. http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/AFST\/Files\/EUCAST_E_Def_7_3_Yeast_testing_definitive.pdf."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.2307\/3760427"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02345-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02345-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:18:26Z","timestamp":1645478306000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02345-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1128\/AAC.02345-17"],"URL":"https:\/\/doi.org\/10.1128\/aac.02345-17","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"2017-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02345-17"}}