{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:39:15Z","timestamp":1783021155143,"version":"3.54.6"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["CSIR-SRF"],"award-info":[{"award-number":["CSIR-SRF"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n            In a focused exploration, we designed, synthesized, and biologically evaluated chiral conjugated new chloroquine (CQ) analogues with substituted piperazines as antimalarial agents.\n            <jats:italic>In vitro<\/jats:italic>\n            as well as\n            <jats:italic>in vivo<\/jats:italic>\n            studies revealed that compound 7c showed potent activity (\n            <jats:italic>in vitro<\/jats:italic>\n            50% inhibitory concentration, 56.98 nM for strain 3D7 and 97.76 nM for strain K1; selectivity index\n            <jats:italic>in vivo<\/jats:italic>\n            [up to at a dose of 12.5\u2009mg\/kg of body weight], 3,510) as a new lead antimalarial agent.\n          <\/jats:p>","DOI":"10.1128\/aac.02347-17","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T14:09:45Z","timestamp":1537193385000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Synthesis, Biological Evaluation, and Molecular Modeling Studies of Chiral Chloroquine Analogues as Antimalarial Agents"],"prefix":"10.1128","volume":"62","author":[{"given":"Srinivasarao","family":"Kondaparla","sequence":"first","affiliation":[{"name":"Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9776-2391","authenticated-orcid":false,"given":"Utsab","family":"Debnath","sequence":"additional","affiliation":[{"name":"Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awakash","family":"Soni","sequence":"additional","affiliation":[{"name":"Parasitology Division, CSIR-Central Drug Research Institute, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasantha Rao","family":"Dola","sequence":"additional","affiliation":[{"name":"Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Sinha","sequence":"additional","affiliation":[{"name":"Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumkum","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Parasitology Division, CSIR-Central Drug Research Institute, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil K.","family":"Puri","sequence":"additional","affiliation":[{"name":"Parasitology Division, CSIR-Central Drug Research Institute, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seturam B.","family":"Katti","sequence":"additional","affiliation":[{"name":"Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200600240"},{"key":"e_1_3_3_3_2","volume-title":"World malaria report","author":"World Health Organization","year":"2016","unstructured":"World Health Organization. 2016. 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