{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:18:17Z","timestamp":1791425897951,"version":"4.3.3"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Stable resistance to metronidazole in a nontoxigenic\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Clostridium difficile<\/jats:named-content>\n            strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress.\n          <\/jats:p>","DOI":"10.1128\/aac.02350-14","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T07:42:17Z","timestamp":1402386137000},"page":"4957-4960","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":49,"title":["Multidisciplinary Analysis of a Nontoxigenic Clostridium difficile Strain with Stable Resistance to Metronidazole"],"prefix":"10.1128","volume":"58","author":[{"given":"Ines","family":"Moura","sequence":"first","affiliation":[{"name":"Department of Infectious, Parasitic, and Immune-Mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Monot","sequence":"additional","affiliation":[{"name":"Laboratoire Pathogen\u00e8se des Bact\u00e9ries Ana\u00e9robies, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Tani","sequence":"additional","affiliation":[{"name":"Structural Mass Spectrometry and Proteomics Unit, Novartis Vaccines &amp; Diagnostics, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Spigaglia","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic, and Immune-Mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Barbanti","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic, and Immune-Mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Norais","sequence":"additional","affiliation":[{"name":"Structural Mass Spectrometry and Proteomics Unit, Novartis Vaccines &amp; Diagnostics, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Dupuy","sequence":"additional","affiliation":[{"name":"Laboratoire Pathogen\u00e8se des Bact\u00e9ries Ana\u00e9robies, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Bouza","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Mastrantonio","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic, and Immune-Mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00082-09"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1054\/drup.1999.0104"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2011.631029"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00524-08"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053757"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks420"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bap021"},{"key":"e_1_3_2_9_2","volume-title":"Approved standard M11-A7","author":"Clinical and Laboratory Standards Institute","year":"2007","unstructured":"Clinical and Laboratory Standards Institute. 2007. 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