{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:03:11Z","timestamp":1791414191870,"version":"4.3.3"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The pleuromutilin antibiotic lefamulin demonstrated\n                    <jats:italic>in vitro<\/jats:italic>\n                    activity against the most relevant bacterial pathogens causing sexually transmitted infections (STI), including\n                    <jats:named-content content-type=\"genus-species\">Chlamydia trachomatis<\/jats:named-content>\n                    (MIC\n                    <jats:sub>50\/90<\/jats:sub>\n                    , 0.02\/0.04 mg\/liter;\n                    <jats:italic>n<\/jats:italic>\n                    = 15), susceptible and multidrug-resistant\n                    <jats:named-content content-type=\"genus-species\">Mycoplasma genitalium<\/jats:named-content>\n                    (MIC range, 0.002 to 0.063 mg\/liter;\n                    <jats:italic>n<\/jats:italic>\n                    = 6), and susceptible and resistant\n                    <jats:named-content content-type=\"genus-species\">Neisseria gonorrhoeae<\/jats:named-content>\n                    (MIC\n                    <jats:sub>50\/90<\/jats:sub>\n                    , 0.12\/0.5 mg\/liter;\n                    <jats:italic>n<\/jats:italic>\n                    = 25). The results suggest that lefamulin could be a promising first-line antibiotic for the treatment of STI, particularly in populations with high rates of resistance to standard-of-care antibiotics.\n                  <\/jats:p>","DOI":"10.1128\/aac.02380-17","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T08:58:14Z","timestamp":1520931494000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":61,"title":["<i>In Vitro<\/i>\n                    Activity of Lefamulin against Sexually Transmitted Bacterial Pathogens"],"prefix":"10.1128","volume":"62","author":[{"given":"Susanne","family":"Paukner","sequence":"first","affiliation":[{"name":"Nabriva Therapeutics GmbH, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Gruss","sequence":"additional","affiliation":[{"name":"Nabriva Therapeutics GmbH, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-7435","authenticated-orcid":false,"given":"J\u00f8rgen Skov","family":"Jensen","sequence":"additional","affiliation":[{"name":"Statens Serum Institut, Microbiology and Infection Control, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143304"},{"key":"e_1_3_3_3_2","volume-title":"Department of Health and Human Services","author":"Centers for Disease Control and Prevention","year":"2015","unstructured":"Centers for Disease Control and Prevention. 2015. 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