{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:15:42Z","timestamp":1791296142582,"version":"4.1.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100002141","name":"Public Health England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["WT089051"],"award-info":[{"award-number":["WT089051"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and\n                    <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n                    parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of\n                    <jats:italic>pfk13<\/jats:italic>\n                    -mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.\n                  <\/jats:p>","DOI":"10.1128\/aac.02382-16","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T21:50:39Z","timestamp":1485813039000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":106,"title":["<i>pfk13<\/i>\n                    -Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom"],"prefix":"10.1128","volume":"61","author":[{"given":"Colin J.","family":"Sutherland","sequence":"first","affiliation":[{"name":"Public Health England Malaria Reference Laboratory, London School of Hygiene &amp; Tropical Medicine, London, United Kingdom"},{"name":"Department of Immunology &amp; Infection, Faculty of Infectious &amp; Tropical Diseases, London School of Hygiene &amp; Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lansdell","sequence":"additional","affiliation":[{"name":"Public Health England Malaria Reference Laboratory, London School of Hygiene &amp; Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Sanders","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Muwanguzi","sequence":"additional","affiliation":[{"name":"Department of Immunology &amp; Infection, Faculty of Infectious &amp; Tropical Diseases, London School of Hygiene &amp; Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donelly A.","family":"van Schalkwyk","sequence":"additional","affiliation":[{"name":"Department of Immunology &amp; Infection, Faculty of Infectious &amp; Tropical Diseases, London School of Hygiene &amp; Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harparkash","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Immunology &amp; 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