{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:30:33Z","timestamp":1790188233797,"version":"4.1.0"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"South African National Research Foundation","award":["IFR170227223728"],"award-info":[{"award-number":["IFR170227223728"]}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:p>Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population pharmacokinetic meta-analysis was conducted using individual participant data from 10 studies with 6,100 lumefantrine concentrations from 793 nonpregnant adult participants (41% HIV-malaria-coinfected, 36% malaria-infected, 20% HIV-infected, and 3% healthy volunteers).<\/jats:p>","DOI":"10.1128\/aac.02394-19","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T13:16:12Z","timestamp":1581945372000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["An Individual Participant Data Population Pharmacokinetic Meta-analysis of Drug-Drug Interactions between Lumefantrine and Commonly Used Antiretroviral Treatment"],"prefix":"10.1128","volume":"64","author":[{"given":"Jose","family":"Francis","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"},{"name":"WorldWide Antimalarial Resistance Network (WWARN) Pharmacology\/Southern African Regional Centre, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5547-820X","authenticated-orcid":false,"given":"Karen I.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"},{"name":"WorldWide Antimalarial Resistance Network (WWARN) Pharmacology\/Southern African Regional Centre, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Workman","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"},{"name":"WorldWide Antimalarial Resistance Network (WWARN) Pharmacology\/Southern African Regional Centre, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Kredo","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"},{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse S.","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Muheza District Hospital, Muheza, Tanzania"},{"name":"Global Health Section, Department of Public Health, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Infectious Disease Epidemiology and Prevention, and Parasitology Laboratory, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Hoglund","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Byakika-Kibwika","sequence":"additional","affiliation":[{"name":"Department of Medicine, Makerere University, Kampala, Uganda"},{"name":"Infectious Diseases Institute, Makerere University, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Lamorde","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen I.","family":"Walimbwa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeyinwa","family":"Chijioke-Nwauche","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Management, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1592-6407","authenticated-orcid":false,"given":"Colin J.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene &amp; Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepta","family":"Merry","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Trinity College, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley K.","family":"Scarsi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyagonde","family":"Nyagonde","sequence":"additional","affiliation":[{"name":"Muheza District Hospital, Muheza, Tanzania"},{"name":"Tanga Research Centre, National Institute for Medical Research (NIMR), Tanga, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha M.","family":"Lemnge","sequence":"additional","affiliation":[{"name":"Tanga Research Centre, National Institute for Medical Research (NIMR), Tanga, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saye H.","family":"Khoo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ib C.","family":"Bygbjerg","sequence":"additional","affiliation":[{"name":"Global Health Section, Department of Public Health, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca T.","family":"Aweeka","sequence":"additional","affiliation":[{"name":"Drug Research Unit, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4566-4030","authenticated-orcid":false,"given":"Joel","family":"Tarning","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"},{"name":"WorldWide Antimalarial Resistance Network (WWARN) Pharmacometrics\/Asia Regional Centre, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7494-079X","authenticated-orcid":false,"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"},{"name":"WorldWide Antimalarial Resistance Network (WWARN) Pharmacology\/Southern African Regional Centre, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01785.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01784.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01312-10"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199937020-00002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0928-0987(99)00037-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.112136"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181acb4ff"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr596"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1345-1"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31826ebb5c"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0695-2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2015.37"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01153-15"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05265-11"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12529"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks207"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02508-12"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.048918"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01310-18"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2017.05.056"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0456-7"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002579"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.9.081307.164258"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu286"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw291"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/393976"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2017.05.043"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835cae3b"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02637.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw710"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2008.78.241"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2018-000999"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0031"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis747"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30048-8"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00868-17"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2404-4"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01140-19"},{"key":"e_1_3_2_45_2","volume-title":"NONMEM user\u2019s guides (1989\u20132009)","author":"Beal S","year":"2009","unstructured":"Beal S, Sheiner LBL, Boeckmann A, Bauer RRJ. 2009. NONMEM user\u2019s guides (1989\u20132009). ICON Development Solutions, Ellicott City, MD."},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2013.24"},{"key":"e_1_3_2_47_2","unstructured":"R Development Core Team. 2013. R: a language and environment for statistical computing. R Foundation for Statistical Computing Vienna Austria."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-007-9066-0"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.48.113006.094708"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1012299115260"},{"key":"e_1_3_2_51_2","first-page":"14","volume-title":"Abstracts of the Annual Meeting of the Population Approach Group in Europe","author":"Holford N","year":"2005","unstructured":"Holford N. 2005. The visual predictive check superiority to standard diagnostic (Rorschach) plots, p 14. In Abstracts of the Annual Meeting of the Population Approach Group in Europe, Pamplona, Spain."},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-016-9487-8"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04205.x"},{"key":"e_1_3_2_54_2","volume-title":"Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria in HIV-positive Tanzanian adults receiving first-line antiretrovirals","author":"Vestergaard L","year":"2013","unstructured":"Vestergaard L, Nyagonde N, Cundill B, Duong T, Sebe W, Francis F, Persson O, Helleberg M, Asbjoern J, Amos B, Wiesner L, Barnes K, Alifrangis M, Lemnge M, Bygbjerg I. 2013. Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria in HIV-positive Tanzanian adults receiving first-line antiretrovirals. Multilateral Initiative on Malaria (MIM) Congress, Durban, South Africa. https:\/\/researchonline.lshtm.ac.uk\/id\/eprint\/1300527\/."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02394-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02394-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:46:10Z","timestamp":1645479970000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02394-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,4,21]]}},"alternative-id":["10.1128\/AAC.02394-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.02394-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,21]]},"assertion":[{"value":"2019-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02394-19"}}