{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:01:56Z","timestamp":1791414116780,"version":"4.3.3"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The activity of plazomicin and clinically relevant aminoglycosides was tested against 346 extended-spectrum-\u03b2-lactamase\/AmpC-producing\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            urinary isolates, and the results were correlated with the presence of aminoglycoside-modifying enzymes (AMEs). Data showed that plazomicin was very active against all ESBL\/AmpC-producing\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            urinary isolates. Its activity was not related to the AME genes studied.\n          <\/jats:p>","DOI":"10.1128\/aac.02454-16","type":"journal-article","created":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T03:00:36Z","timestamp":1480993236000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Plazomicin Activity against 346 Extended-Spectrum-\u03b2-Lactamase\/AmpC-Producing Escherichia coli Urinary Isolates in Relation to Aminoglycoside-Modifying Enzymes"],"prefix":"10.1128","volume":"61","author":[{"given":"Maria del Carmen","family":"L\u00f3pez-Diaz","sequence":"first","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Culebras","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iciar","family":"Rodr\u00edguez-Avial","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Rios","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Vi\u00f1uela-Prieto","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Picazo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina (Microbiolog\u00eda), Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Rodr\u00edguez-Avial","sequence":"additional","affiliation":[{"name":"Departamento de Medicina (Microbiolog\u00eda), Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.02.008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00688-09"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.08.003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2015.1095180"},{"key":"e_1_3_2_6_2","unstructured":"U.S. National Institutes of Health. http:\/\/clinicaltrials.gov."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.2.500-510.2002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.6.2153-2162.2002"},{"key":"e_1_3_2_9_2","volume-title":"Performance standards for antimicrobial susceptibility testing. 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