{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:01:38Z","timestamp":1783512098171,"version":"3.55.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI087674"],"award-info":[{"award-number":["R01 AI087674"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004628","name":"MedImmune","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The role broad-spectrum antibiotics play in the spread of antimicrobial resistance, coupled with their effect on the healthy microbiome, has led to advances in pathogen-specific approaches for the prevention or treatment of serious bacterial infections. One approach in clinical testing is passive immunization with a monoclonal antibody (MAb) targeting alpha toxin for the prevention or treatment of\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            pneumonia. Passive immunization with the human anti-alpha toxin MAb, MEDI4893*, has been shown to improve disease outcome in murine\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            pneumonia models. The species specificity of some\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            toxins necessitates testing anti-\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            therapeutics in alternate species. We developed a necrotizing pneumonia model in ferrets and utilized an existing rabbit pneumonia model to characterize MEDI4893* protective activity in species other than mice. MEDI4893* prophylaxis reduced disease severity in ferret and rabbit pneumonia models against both community-associated methicillin-resistant\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            (MRSA) and hospital-associated MRSA strains. In addition, adjunctive treatment of MEDI4893* with either vancomycin or linezolid provided enhanced protection in rabbits relative to the antibiotics alone. These results confirm that MEDI4893 is a promising candidate for immunotherapy against\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            pneumonia.\n          <\/jats:p>","DOI":"10.1128\/aac.02456-16","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T02:40:19Z","timestamp":1485225619000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia"],"prefix":"10.1128","volume":"61","author":[{"given":"Binh An","family":"Diep","sequence":"first","affiliation":[{"name":"Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamese J.","family":"Hilliard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, MedImmune, LLC, Gaithersburg, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vien T. M.","family":"Le","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Tkaczyk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, MedImmune, LLC, Gaithersburg, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoan N.","family":"Le","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuvi G.","family":"Tran","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee L.","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etyene Castro","family":"Dip","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane P.","family":"Pereira-Franchi","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulyn","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Applied Immunology and Microbiology, MedImmune, LLC, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Applied Immunology and Microbiology, MedImmune, LLC, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Broome","sequence":"additional","affiliation":[{"name":"Department of Applied Immunology and Microbiology, MedImmune, LLC, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily I.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Translational Sciences, MedImmune, LLC, Gaithersburg, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Weiss","sequence":"additional","affiliation":[{"name":"Pre-Clinical Services, University of North Texas Health Sciences Center, Fort Worth, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-3458","authenticated-orcid":false,"given":"Laszlo","family":"Prokai","sequence":"additional","affiliation":[{"name":"Pre-Clinical Services, University of North Texas Health Sciences Center, Fort Worth, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Pre-Clinical Services, University of North Texas Health Sciences Center, Fort Worth, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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